Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity

被引:44
作者
Kaiser, Felix [1 ,2 ]
Schmidt, Andrea [1 ,2 ]
Heydenreuter, Wolfgang [3 ]
Altmann, Philipp J. [1 ,2 ]
Casini, Angela [4 ,5 ]
Sieber, Stephan A. [3 ]
Kuehn, Fritz E. [1 ,2 ]
机构
[1] Tech Univ Munich, Catalysis Res Ctr, Lichtenbergstr 4, D-85747 Garching, Germany
[2] Tech Univ Munich, Dept Chem, Lichtenbergstr 4, D-85747 Garching, Germany
[3] Tech Univ Munich, Dept Chem, Ctr Integrated Prot Sci Munich, Lichtenbergstr 4, D-85747 Garching, Germany
[4] Cardiff Univ, Sch Chem, Pk Pl, Cardiff CF10 3AT, S Glam, Wales
[5] Tech Univ Munich, Inst Adv Study, Lichtenbergstr 2a, D-85748 Garching, Germany
关键词
Medicinal chemistry; Drug delivery; Antitumor agents; Cisplatin; Cage compounds; Self-assembly; M2L4 MOLECULAR CAPSULES; DRUG-DELIVERY; CRYSTAL-STRUCTURES; ANTHRACENE SHELLS; COMPLEXES; CISPLATIN; ENCAPSULATION; LIGANDS; CANCER; ANION;
D O I
10.1002/ejic.201600811
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Self-assembled coordination cages are interesting as drug-delivery systems. Therefore, the synthesis of new M2L4 (M = Pd, Pt) molecular cages derived from highly fluorescent, rigid polyaromatic ligands is reported herein, and the first Pt2L4 cage with a ligand consisting of three pyridine moieties is described. The photophysical properties were examined, and they showed high quantum yields phi of up to 48% for the methoxy-functionalized ligands. Coordination of the ligands to palladium and platinum ions did, however, reduce the fluorescence of the metallocages. The host-guest chemistry of the palladium cages with cisplatin was investigated, which confirmed the encapsulation. The cages encapsulating cisplatin show significantly increased cytotoxicity towards A549 (human lung adenocarcinoma) cells relative to that shown by cisplatin and, thus, appear to be promising delivery vectors for the anticancer drug cisplatin.
引用
收藏
页码:5189 / 5196
页数:8
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