The -491A/T polymorphism of the apolipoprotein E gene is associated with the ApoEε4 allele and Alzheimer's Disease

被引：23

作者：

Ahmed, ARH

MacGowan, SH ^{[1
]}

Culpan, D

Jones, RW

Wilcock, GK

机构：

[1] Univ Bristol, Frenchay Day Hosp Lab, Dept Care Elderly, Frenchay Hosp, Bristol BS16 1LE, Avon, England

[2] St Martins Hosp, Res Inst Care Elderly, Bath BA2 5RP, Avon, England

来源：

NEUROSCIENCE LETTERS | 1999年 / 263卷 / 2-3期

关键词：

Alzheimer's disease; -491 A/T polymorphism; ApoE epsilon 4; gender;

D O I：

10.1016/S0304-3940(99)00126-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several studies have attempted to confirm the association between the recently reported polymorphism located at position -491 in the transcriptional regulatory region of the Apolipoprotein E (ApoE) gene and Alzheimer's disease (AD). Results have been inconclusive, possibly due to the use or clinically diagnosed subjects and controls only. In this retrospective case-control study of 149 (96 AD and 53 controls) brain samples we show that homozygosity for the -491A variant is associated with an increased risk of development of AD. The genotype is also strongly associated with the presence of at least one epsilon 4 allele (an established risk factor for AD) in women but not in men. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：217 / 219

页数：3

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