Topography of evoked brain activity during mental arithmetic and language tasks: sex differences

We studied visual information processing using two different tasks in a group of 10 female and 10 male healthy, right-handed adults. Subjects solved arithmetic tasks shown sequentially on a computer monitor, and they also compared words presented as anagrams. The experimental design allowed us to compare the effects of reading or actively processing a given stimulus. Task difficulty was varied in three steps ('easy', 'medium', 'hard') after an independent group of 81 young adults had judged the stimulus material according to difficulty by answering questionnaires. Brain activity was recorded from an array of 30 electrodes extending from the inion to 5% anterior of F-2. For each subject mean potentials were averaged off-line after screening the EEG for artifacts. Components were determined quantitatively as epochs of stable topography resulting in 10 independent components occurring within 1200 ms after stimulus onset. Significant effects were seen with field strength and scalp topography: simply reading the stimuli yielded significantly smaller amplitudes than when the subjects actively processed the same stimuli. Females had consistently larger global field power than males, and they also displayed different scalp field topography of various components. In addition, processing anagrams was accompanied by larger field strength than mental arithmetic. The scalp field distributions were also affected by sex, task type and difficulty indicating the activation of different neuronal assemblies during visual information processing of males and females. Many effects were seen at short latencies in the order of 70-120 ms indicating very early selective processing of visual stimuli where specific differences were introduced by sex and task parameters. (C) 1999 Elsevier Science Ltd. All rights reserved.