The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals

被引：14

作者：

Burette, Alain C. ^{[1
]}

Weinberg, Richard J. ^{[1
,2
]}

Sassani, Patrick ^{[3
]}

Abuladze, Natalia ^{[3
]}

Kao, Liyo ^{[3
]}

Kurtz, Ira ^{[3
,4
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

JOURNAL OF COMPARATIVE NEUROLOGY | 2012年 / 520卷 / 07期

基金：

美国国家卫生研究院;

关键词：

synaptic vesicle; glutamate; GABA; pH; VGLUT; VGAT; SLC4A8; GAMMA-AMINOBUTYRIC-ACID; VESICULAR GLUTAMATE TRANSPORTER; SYNAPTIC VESICLES; INTRACELLULAR PH; QUANTAL SIZE; FUNCTIONAL RECONSTITUTION; HIPPOCAMPAL-NEURONS; ENERGY-DEPENDENCE; PYRAMIDAL NEURONS; BRAIN;

D O I：

10.1002/cne.22806

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The sodium-driven chloride/bicarbonate exchanger (NDCBE), a member of the SLC4 family of bicarbonate transporters, was recently found to modulate excitatory neurotransmission in hippocampus. By using light and electron microscopic immunohistochemistry, we demonstrate here that NDCBE is expressed throughout the adult rat brain, and selectively concentrates in presynaptic terminals, where it is closely associated with synaptic vesicles. NDCBE is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive ?-aminobutyric acid (GABA)ergic cells. These findings suggest that NDCBE can regulate glutamatergic transmission throughout the brain, and point to a role for NDCBE as a possible regulator of GABAergic neurotransmission. J. Comp. Neurol. 520:14811492, 2012. (c) 2011 Wiley Periodicals, Inc.

引用

页码：1481 / 1492

页数：12

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