Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

被引：308

作者：

Molloy, SS ^{[1
]}

Anderson, ED ^{[1
]}

Jean, F ^{[1
]}

Thomas, G ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA

来源：

TRENDS IN CELL BIOLOGY | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0962-8924(98)01382-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Furin is a secretory Pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, In multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into, early embryogenesis, extracellular matrix formation and pathogen virulence.

引用

页码：28 / 35

页数：8

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