Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors

被引：3

作者：

Turan, Ozden ^{[1
]}

Anuk-Ince, Deniz ^{[1
]}

Olcay, Lale ^{[2
]}

Sezer, Taner ^{[3
]}

Gulleroglu, Kaan ^{[4
]}

Yilmaz-Celik, Zerrin ^{[5
]}

Ecevit, Ayse ^{[1
]}

机构：

[1] Baskent Univ, Fac Med, Div Neonatol, Ankara, Turkey

[2] Baskent Univ, Fac Med, Div Pediat Hematol, Ankara, Turkey

[3] Baskent Univ, Fac Med, Div Pediat Neurol, Ankara, Turkey

[4] Baskent Univ, Fac Med, Div Pediat Nephrol, Ankara, Turkey

[5] Baskent Univ, Fac Med, Dept Med Genet, Ankara, Turkey

来源：

TURKISH JOURNAL OF PEDIATRICS | 2017年 / 59卷 / 01期

关键词：

anticoagulation; cerebral sinovenous thrombosis; newborn; VENOUS THROMBOSIS; CHILDREN;

D O I：

10.24953/turkjped.2017.01.012

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Cerebral sinovenous thrombosis (CSVT) is a rare disease in the neonatal period and also the greatest risk of neonatal mortality and morbidity. In this report, we presented two cases with CSVT and different risk factors. One of these cases had methylenetetrahydrofolate reductase (MTHFR) C677T homozygous polymorphism and the other case had both MTHFR A1298C homozygous polymorphism, plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and elevated lipoprotein a. Early diagnosis and prompt initiation of therapy of neonatal CSVT may prevent neonatal mortality and poor long-term neurodevelopmental outcomes.

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收藏

页码：71 / 75

页数：5

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