Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARDI 5 variants consistently predict phenotypic characteristics of severe disease

被引：76

作者：

Russell, RK

Drummond, HE

Nimmo, EE

Anderson, N

Smith, L

Wilson, DC

Gillett, PM

McGrogan, P

Hassan, K

Weaver, LT

Bisset, M

Mahdi, G

Satsangi, J

机构：

[1] Western Gen Hosp, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[3] Royal Hosp Sick Children, Dept Child Life & Hlth, Edinburgh EH9 1LF, Midlothian, Scotland

[4] Royal Hosp Sick Children, Dept Pediat Gastroenterol & Nutr, Edinburgh EH9 1LF, Midlothian, Scotland

[5] Yorkhill Hosp, Dept Pediat Gastroenterol, Glasgow, Lanark, Scotland

[6] Univ Glasgow, Dept Child Hlth, Glasgow G12 8QQ, Lanark, Scotland

[7] Royal Aberdeen Childrens Hosp, Dept Pediat Gastroenterol, Aberdeen, Scotland

来源：

INFLAMMATORY BOWEL DISEASES | 2005年 / 11卷 / 11期

基金：

英国惠康基金;

关键词：

childhood; Crohn's disease; NOD2/CARD15; phenotype; surgery;

D O I：

10.1097/01.MIB.0000183423.38037.f3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish early-onset IBD population.

引用

页码：955 / 964

页数：10

共 63 条

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