Confirmations, advances and recommendations for the daily care of schizophrenia based on the French national FACE-SZ cohort

被引：13

作者：

Fond, G. ^{[1
,3
]}

Godin, O. ^{[1
]}

Schurhoff, F. ^{[1
,2
]}

Berna, F. ^{[1
,5
]}

Andre, M. ^{[1
,6
]}

Aouizerate, B. ^{[1
,4
,12
]}

Capdevielle, D. ^{[1
,6
]}

Chereau, I. ^{[1
,7
]}

D'Amato, T. ^{[1
,8
]}

Dubertret, C. ^{[1
,9
]}

Dubreucq, J. ^{[1
,10
]}

Faget, C. ^{[1
,3
]}

Lancon, C. ^{[1
,3
]}

Leignier, S. ^{[1
,10
]}

Mallet, J. ^{[1
,9
]}

Misdrahi, D. ^{[1
,13
]}

Passerieux, C. ^{[1
,11
]}

Pignon, B. ^{[1
,2
]}

Rey, R. ^{[1
]}

Szoke, A. ^{[1
,2
]}

Urbach, M. ^{[1
,11
]}

Vidailhet, P. ^{[5
]}

Leboyer, M. ^{[1
,2
]}

Boyer, L. ^{[1
,3
]}

Llorca, P. M. ^{[1
,7
]}

机构：

[1] Fdn FondaMental, Creteil, France

[2] Univ Paris Est Creteil, Pole Psychiat Hop Univ H Mondor, DHU Pe PSY, INSERM,U955,Equipe Psychiat Translat, Creteil, France

[3] Aix Marseille Univ, Fac Med Secteur, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, EA 3279,LaTimone, 27 Blvd Jean Moulin, F-13005 Marseille, France

[4] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France

[5] Univ Strasbourg, Hop Univ Strasbourg, INSERM, U1114,Federat Med Translat Strasbourg, Strasbourg, France

[6] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,INSERM, F-1061 Montpellier, France

[7] Univ Auvergne, CHU Clermont Ferrand, Fac Med, CMP B,EA 7280, BP 69, F-63003 Clermont Ferrand 1, France

[8] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, Ctr Hosp Le Vinatier, CNRS,UMR5292,INSERM,U1028,Equipe PSYR2, Pole Est,95 Bd Pinel,BP 30039, F-69678 Bron, France

[9] Univ Paris Diderot, Louis Mourier Hosp, AP HP, Sorbonne Paris Cite,INSERM,U894,Dept Psychiat, Colombes, France

[10] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France

[11] Univ Versailles St Quentin En Yvelines, Ctr Hosp Versailles, UFR Sci Sante Simone Veil, Serv Psychiat & Daddictol Adulte,HANDIReSP,EA 404, Versailles, France

[12] Univ Bordeaux, INRA, NutriNeuro, U1286, F-33076 Bordeaux, France

[13] CNRS, INCIA, UMR 5287, Paris, France

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2020年 / 101卷

关键词：

Schizophrenia; Cohort; FACE-SZ; Daily practice; Recommendations; QUALITY-OF-LIFE; CHILDHOOD TRAUMA; RATING-SCALE; NICOTINE DEPENDENCE; COGNITIVE INSIGHT; LANGUAGE VERSION; VALIDATION; VALIDITY; RELIABILITY; DISORDERS;

D O I：

10.1016/j.pnpbp.2020.109927

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The National FondaMental Centers of Expertise (FACE) for Schizophrenia (SZ) have been created to shorten the gap between research and clinical practice. Objectives To synthetize in a review the 10-year findings issued from the FACE-SZ cohort analyses. Methods More than 1000 patients were evaluated in 10 expert centers since 2010 with a 2-day long comprehensive standardized battery including neuropsychological testes and physical health assessment and followed-up for 3years. Results 1. The phase 0 cross-sectional analyses have confirmed well-known data: over-prescription of first-generation antipsychotics, antipsychotic polytherapy and long-term benzodiazepine and under-prescription of clozapine, 13% of drug-induced parkinsonism, 18% of akathisia, a mean duration of untreated psychosis of 18months, one third of poorly-adherent patients, 24% of metabolic syndrome and 52% of current tobacco smokers with poor care for physical illnesses; a yearly mean financial cost of 15,000 euro/patient. 2. FACE-SZ also yielded additional data in insufficiently explored area: a half of major depression issues (among them one third of undiagnosed major depression and 44% of treated patients with unremitted depression), major depression having a strong impact on Quality of Life independently of negative symptoms, 22% of moderated to severe untreated physical pain. 3. FACE-SZ has explored emerging fields of research, including development of 4 stages- model of schizophrenia, chronic low-grade peripheral inflammation, latent Toxoplasma infection, hypovitaminosis D, and a model for relapse prediction at 2years. Discussion The associated factors and implications for public health programs were discussed. Based on the FACE-SZ findings and literature, the FACE-SZ group has yielded recommendations to improve daily care for schizophrenia and for future research.

引用

页数：9

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