The Role of Asymmetric Dimethyl Arginine and Oxidant/Antioxidant System in Preeclampsia

被引：13

作者：

Alacam, Hasan ^{[2
]}

Dikmen, Gunnur ^{[2
]}

Yaman, Halil ^{[1
]}

Cakir, Erdinc ^{[1
]}

Deren, Ozgur ^{[3
]}

Akgul, E. Ozgur ^{[1
]}

Aydin, Ibrahim ^{[1
]}

Kurt, Yasemin Gulcan ^{[1
]}

Keskin, Ugur ^{[4
]}

Akalin, Sukran ^{[5
]}

Polat, Belgin ^{[6
]}

Danisman, Nuri ^{[6
]}

Dogan, Pakize ^{[2
]}

机构：

[1] Gulhane Mil Med Acad, Dept Med Biochem, TR-06018 Ankara, Turkey

[2] Hacettepe Univ, Sch Med, Dept Med Biochem, Ankara, Turkey

[3] Hacettepe Univ, Sch Med, Dept Gynecol & Obstet, Ankara, Turkey

[4] Gulhane Mil Med Acad, Dept Gynecol & Obstet, TR-06018 Ankara, Turkey

[5] Ankara Teaching & Res Hosp, Dept Gynecol & Obstet, Ankara, Turkey

[6] Zekai Tahir Burak Woman Hlth Care Teaching & Res, Dept Gynecol & Obstet, Ankara, Turkey

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2011年 / 30卷 / 06期

关键词：

preeclampsia; ADMA; antioxidant enzymes; malondialdehyde (MDA); OXIDATIVE STRESS; ENZYME-ACTIVITY; NITRIC-OXIDE; DIMETHYLAMINOHYDROLASE; DISEASE; PLASMA; ASSAY; ADMA;

D O I：

10.3109/15513815.2011.618869

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Preeclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study is to find the relationship between preeclampsia, asymmetric dimethyl arginine (ADMA), and the oxidant/antioxidant system. Twenty-one preeclamptic and 28 normal pregnant women were included in this study. In cord bloods, ADMA and oxidant/antioxidant parameters were measured. Asymmetric dimethyl arginine levels were significantly increased in preeclamptic pregnancies compared to the control group (p = 0.006). The activities of antioxidant enzymes and malondialdehyde levels were increased in the preeclamptic group compared to the control group (p < 0.001, p = 0.022, p < 0.001, p < 0.001, respectively). Development of endothelial dysfunction and oxidative stress may play a role in developing preeclampsia.

引用

页码：387 / 393

页数：7

共 22 条

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