Treating metastatic cancer with nanotechnology

被引：929

作者：

Schroeder, Avi ^{[1
,2
]}

Heller, Daniel A. ^{[1
,2
]}

Winslow, Monte M. ^{[1
,3
]}

Dahlman, James E. ^{[1
,4
]}

Pratt, George W. ^{[1
,2
]}

Langer, Robert ^{[1
,2
,4
]}

Jacks, Tyler ^{[1
,5
,6
,7
]}

Anderson, Daniel G. ^{[1
,2
,4
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[4] MIT, Harvard Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[6] MIT, Ludwig Ctr Mol Oncol, Cambridge, MA 02139 USA

[7] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

BLOOD-BRAIN-BARRIER; PEGYLATED LIPOSOMAL DOXORUBICIN; INTENSITY FOCUSED ULTRASOUND; TUMOR-CELL EXTRAVASATION; LIPID-LIKE MATERIALS; DRUG-DELIVERY; IN-VIVO; IRON-OXIDE; COMPLEMENT ACTIVATION; APOLIPOPROTEIN-E;

D O I：

10.1038/nrc3180

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis accounts for the vast majority of cancer deaths. The unique challenges for treating metastases include their small size, high multiplicity and dispersion to diverse organ environments. Nanoparticles have many potential benefits for diagnosing and treating metastatic cancer, including the ability to transport complex molecular cargoes to the major sites of metastasis, such as the lungs, liver and lymph nodes, as well as targeting to specific cell populations within these organs. This Review highlights the research, opportunities and challenges for integrating engineering sciences with cancer biology and medicine to develop nanotechnology-based tools for treating metastatic disease.

引用

页码：39 / 50

页数：12

共 227 条

[1] Development of a Tumor-Selective Approach to Treat Metastatic Cancer [J].

Aboody, Karen S. ;

Bush, Rebecca A. ;

Garcia, Elizabeth ;

Metz, Marianne Z. ;

Najbauer, Joseph ;

Justus, Kristine A. ;

Phelps, Doris A. ;

Remack, Joanna S. ;

Yoon, Karina Jin ;

Gillespie, Shanna ;

Kim, Seung U. ;

Glackin, Carlotta A. ;

Potter, Philip M. ;

Danks, Mary K. .

PLOS ONE, 2006, 1 (01)

[2] Nanomaterial standards for efficacy and toxicity assessment [J].

Adiseshaiah, Pavan P. ;

Hall, Jennifer B. ;

McNeil, Scott E. .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2010, 2 (01) :99-112

[3] Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes [J].

Afergan, Eyal ;

Epstein, Hila ;

Dahan, Rachel ;

Koroukhov, Nickolay ;

Rohekar, Keren ;

Danenberg, Haim D. ;

Golomb, Gershon .

JOURNAL OF CONTROLLED RELEASE, 2008, 132 (02) :84-90

[4] A combinatorial library of lipid-like materials for delivery of RNAi therapeutics [J].

Akinc, Akin ;

Zumbuehl, Andreas ;

Goldberg, Michael ;

Leshchiner, Elizaveta S. ;

Busini, Valentina ;

Hossain, Naushad ;

Bacallado, Sergio A. ;

Nguyen, David N. ;

Fuller, Jason ;

Alvarez, Rene ;

Borodovsky, Anna ;

Borland, Todd ;

Constien, Rainer ;

de Fougerolles, Antonin ;

Dorkin, J. Robert ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

John, Matthias ;

Koteliansky, Victor ;

Manoharan, Muthiah ;

Nechev, Lubomir ;

Qin, June ;

Racie, Timothy ;

Raitcheva, Denitza ;

Rajeev, Kallanthottathil G. ;

Sah, Dinah W. Y. ;

Soutschek, Juergen ;

Toudjarska, Ivanka ;

Vornlocher, Hans-Peter ;

Zimmermann, Tracy S. ;

Langer, Robert ;

Anderson, Daniel G. .

NATURE BIOTECHNOLOGY, 2008, 26 (05) :561-569

[5] Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms [J].

Akinc, Akin ;

Querbes, William ;

De, Soma ;

Qin, June ;

Frank-Kamenetsky, Maria ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

Rajeev, Kallanthottathil G. ;

Cantley, William L. ;

Dorkin, J. Robert ;

Butler, James S. ;

Qin, LiuLiang ;

Racie, Timothy ;

Sprague, Andrew ;

Fava, Eugenio ;

Zeigerer, Anja ;

Hope, Michael J. ;

Zerial, Marino ;

Sah, Dinah W. Y. ;

Fitzgerald, Kevin ;

Tracy, Mark A. ;

Manoharan, Muthiah ;

Koteliansky, Victor ;

de Fougerolles, Antonin ;

Maier, Martin A. .

MOLECULAR THERAPY, 2010, 18 (07) :1357-1364

[6] Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].

Alexis, Frank ;

Pridgen, Eric ;

Molnar, Linda K. ;

Farokhzad, Omid C. .

MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515

[7]

Ali OA, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000359

[8] SUBCUTANEOUS ADMINISTRATION OF LIPOSOMES - A COMPARISON WITH THE INTRAVENOUS AND INTRAPERITONEAL ROUTES OF INJECTION [J].

ALLEN, TM ;

HANSEN, CB ;

GUO, LSS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1150 (01) :9-16

[9] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[10] Self-assembly of a nanoscale DNA box with a controllable lid [J].

Andersen, Ebbe S. ;

Dong, Mingdong ;

Nielsen, Morten M. ;

Jahn, Kasper ;

Subramani, Ramesh ;

Mamdouh, Wael ;

Golas, Monika M. ;

Sander, Bjoern ;

Stark, Holger ;

Oliveira, Cristiano L. P. ;

Pedersen, Jan Skov ;

Birkedal, Victoria ;

Besenbacher, Flemming ;

Gothelf, Kurt V. ;

Kjems, Jorgen .

NATURE, 2009, 459 (7243) :73-U75

← 1 2 3 4 5 6 7 8 9 10 →