Identification of Giardia lamblia Assemblage E in Humans Points to a New Anthropozoonotic Cycle

被引：126
作者：
Fantinatti, Maria [1 ]
Bello, Alexandre R. [2 ]
Fernandes, Octavio [1 ]
Da-Cruz, Alda M. [1 ,2 ]
机构：
[1] Fundacao Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, Inst Oswaldo Cruz, Rio De Janeiro, Brazil
[2] Univ Estado Rio de Janeiro, Disciplina Parasitol, DMIP, Fac Ciencias Med, Rio De Janeiro, Brazil
来源：
JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷 / 08期
关键词：
Giardia lamblia; beta-giardin gene; assemblage E; molecular characterization; DUODENALIS ASSEMBLAGE; INTESTINALIS; PREVALENCE; GENOTYPES; BIOLOGY; SAMPLES; GENE;
D O I：
10.1093/infdis/jiw361
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Giardia lamblia is a pathogen transmitted by water and food that causes infection worldwide. Giardia genotypes are classified into 8 assemblages (A-H). Assemblages A and B are detected in humans, but they are potentially zoonotic because they infect other mammalian hosts. Giardia in samples from 44 children was genotyped. Conserved fragments of the genes encoding beta-giardin and glutamate dehydrogenase were sequenced and their alignment were carried out with sequences deposited in GenBank. As expected for Rio de Janeiro, the majority of samples were related to assemblage A. Surprisingly, assemblage E was detected in 15 samples. Detection of assemblage E in humans suggests a new zoonotic route of Giardia transmission.
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页码：1256 / 1259
页数：4
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