Differences in diagnosis, treatment, and survival rate of acute myeloid leukemia with or without disabilities: A national cohort study in the Republic of Korea

被引:5
作者
Kwon, Jihyun [1 ,2 ]
Kim, So Young [3 ,4 ,5 ]
Yeob, Kyoung Eun [4 ]
Han, Hye Sook [1 ,2 ]
Lee, Ki Hyeong [1 ,2 ]
Shin, Dong Wook [6 ,7 ]
Kim, Yeon-Yong [8 ]
Park, Jong Heon [8 ]
Park, Jong Hyock [4 ,5 ]
Kawachi, Ichiro [5 ]
机构
[1] Chungbuk Natl Univ Hosp, Dept Internal Med, Div Hematol Oncol, Cheongju, South Korea
[2] Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea
[3] Chungbuk Natl Univ Hosp, Dept Publ Hlth & Prevent Med, Cheongju, South Korea
[4] Chungbuk Natl Univ, Grad Sch Hlth Sci Business Convergence, Coll Med, Cheongju 361763, South Korea
[5] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA
[6] Sungkyunkwan Univ, Samsung Med Ctr, Support Care Ctr, Dept Family Med,Sch Med, Seoul, South Korea
[7] Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Seoul, South Korea
[8] Natl Hlth Insurance Serv, Big Data Steering Dept, Wonju, South Korea
来源
CANCER MEDICINE | 2020年 / 9卷 / 15期
基金
新加坡国家研究基金会;
关键词
acute myeloid leukemia; cohort; disability; survival; treatment; MYELODYSPLASTIC SYNDROMES; CANCER; HEALTH; IMPACT; PEOPLE;
D O I
10.1002/cam4.3179
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We analyzed the patterns of diagnosis, treatment, and prognoses of acute myeloid leukemia (AML) patients with and without disabilities. The data were collected from the National Disability Database, the Korean Central Cancer Registry, and the Korean National Health Insurance claim database. We built a cohort of 2 776 450 people with disabilities and a nondisabled cohort of 8 329 350 people who were selected at a ratio of 1:3 by matching age and sex. From this population, adult patients who were diagnosed with AML were analyzed. The number of patients with AML were 26.74 per 100 000 in people without disabilities and 20.39 per 100 000 in those with disabilities (P < .0001). The proportion of AML patients receiving chemotherapy and those of patients receiving transplants were significantly lower in the disabled population than that of nondisabled populations (71.2% vs 77.1%, P = .0031, and 17.5% vs 26.9%, P = .002). This trend was more pronounced in subgroups of communication disability and major internal organ disorder. The median survival was 10.8 months for patients with disabilities, which was significantly shorter than 17.1 months for those without a disability (P = .002). Individuals with disabilities have a low diagnosis rate of AML and undergo less active treatment, which results in inferior prognosis.
引用
收藏
页码:5335 / 5344
页数:10
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