The Asp298 but not the C-786 genotype of the endothelial nitric oxide synthase is reduced with age in healthy Swiss men

被引：4
作者：
Muntwyler, J
Marti-Jaun, J
Lüscher, TF
Hänseler, E
Hersberger, M
机构：
[1] Univ Zurich Hosp, Ctr Cardiovasc, Div Cardiol, CH-8091 Zurich, Switzerland
[2] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2005年 / 43卷 / 09期
关键词：
atherosclerosis; gene; nitric oxide synthase; polymorphism; risk factor;
D O I：
10.1515/CCLM.2005.167
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：971 / 973
页数：3
相关论文
共 15 条
[1]   Nitric oxide and arterial disease [J].
Barbato, JE ;
Tzeng, E .
JOURNAL OF VASCULAR SURGERY, 2004, 40 (01) :187-193
[2]   Endothelial nitric oxide synthase genotype and ischemic heart disease - Meta-analysis of 26 studies involving 23028 subjects [J].
Casas, JP ;
Bautista, LE ;
Humphries, SE ;
Hingorani, AD .
CIRCULATION, 2004, 109 (11) :1359-1365
[3]  
DAGOSTINO RB, 1989, INT J EPIDEMIOL, V18, pS67
[4]   Acidic hydrolysis as a mechanism for the cleavage of the Glu298 → Asp variant of human endothelial nitric-oxide synthase [J].
Fairchild, TA ;
Fulton, D ;
Fontana, JT ;
Gratton, JP ;
McCabe, TJ ;
Sessa, WC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26674-26679
[5]  
Hersberger M, 2000, CLIN CHEM, V46, P1072
[6]   ENDOTHELIAL NITRIC-OXIDE SYNTHASE - MOLECULAR-CLONING AND CHARACTERIZATION OF A DISTINCT CONSTITUTIVE ENZYME ISOFORM [J].
LAMAS, S ;
MARSDEN, PA ;
LI, GK ;
TEMPST, P ;
MICHEL, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6348-6352
[7]   PATTERNS OF CORONARY HEART-DISEASE MORBIDITY AND MORTALITY IN THE SEXES - A 26-YEAR FOLLOW-UP OF THE FRAMINGHAM POPULATION [J].
LERNER, DJ ;
KANNEL, WB .
AMERICAN HEART JOURNAL, 1986, 111 (02) :383-390
[8]   Functional comparison of the endothelial nitric oxide synthase Glu298 Asp polymorphic variants in human endothelial cells [J].
McDonald, DM ;
Alp, NJ ;
Channon, KM .
PHARMACOGENETICS, 2004, 14 (12) :831-839
[9]   DIFFERENT FREQUENCIES OF ANGIOTENSIN-CONVERTING ENZYME GENOTYPES IN OLDER HYPERTENSIVE INDIVIDUALS [J].
MORRIS, BJ ;
ZEE, RYL ;
SCHRADER, AP .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (03) :1085-1089
[10]   T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm [J].
Nakayama, M ;
Yasue, H ;
Yoshimura, M ;
Shimasaki, Y ;
Kugiyama, K ;
Ogawa, H ;
Motoyama, T ;
Saito, Y ;
Ogawa, Y ;
Miyamoto, Y ;
Nakao, K .
CIRCULATION, 1999, 99 (22) :2864-2870
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