A Comparison of Mesenchymal Stem Cells from Human Adipose Tissues by Resection and by Liposuction

被引：0
作者：
Wang, Le [1 ,2 ]
Wang, Xingqiang [1 ]
Liang, Rui [1 ,2 ]
Wang, Shusen [1 ,3 ]
Cao, Jinglin [4 ]
机构：
[1] Nankai Univ, Tianjin Cent Hosp 1, Organ Transplant Ctr, Tianjin, Peoples R China
[2] NHC Key Lab Crit Care Med, Tianjin, Peoples R China
[3] Tianjin Clin Res Ctr Organ Transplantat, Tianjin, Peoples R China
[4] Hebei Med Univ, Dept Heparobiliary Surg, Hosp 3, 139 Ziqiang Rd, Shijiazhuang, Hebei, Peoples R China
来源：
JOURNAL OF HARD TISSUE BIOLOGY | 2022年 / 31卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Mesenchymal stem cells; Liposuction; Resected fat; Cell vitality; Multi-directional differentiation; STROMAL-VASCULAR FRACTION; HARVESTING SITE; YIELD; DIFFERENTIATION;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Adipose-derived mesenchymal stem cells (ASCs) have showed advantages in the source of therapeutic cells because of their paracrine function, multi-differentiation capacity, and easy access. Liposuction is an appropriate and safe method for obtaining adipose tissue, but little investigation exists regarding the impact of liposuction on the basic characteristics of ASCs. In this study, human ASCs were successfully isolated from liposuction and resected fat tissue. ASCs obtained via liposuction (Lip-ASCs) exhibited indiscriminate signatures when directly compared with resected fat tissue (ResASCs), including morphology, immunophenotype, viability, proliferation, and multi-directional differentiation potential. The comparison of multifaceted characteristics indicated that liposuction is an effective method to obtain and isolate ASCs with high quality, which is suitable for applications in basic research and clinical therapy.
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收藏
页码：15 / 21
页数：7
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