Synthesis of Triazoloquinoxalines as Antitubercular Agents

被引：8

作者：

Sekhar, Kondapalli Venkata Gowri Chandra ^{[1
]}

Rao, Vajja Sambasiva ^{[1
]}

Kumar, Dalip ^{[2
]}

机构：

[1] BITS, Chem Grp, Hyderabad 500078, Andhra Pradesh, India

[2] BITS, Chem Grp, Pilani 333031, Rajasthan, India

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 08期

关键词：

Triazolo quinoxalines; Antitubercular; Iodobenzene diacetate; HETEROCYCLES; DERIVATIVES; ANTIMYCOBACTERIAL; ANTAGONISTS; IODINE; ROUTE;

D O I：

10.5012/bkcs.2011.32.8.2657

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, (1)H NMR, (13)C NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.

引用

页码：2657 / 2660

页数：4

共 50 条

[41] New heterocyclic hydrazones in the search for antitubercular agents:: Synthesis and in vitro evaluations
Bijev, A.
LETTERS IN DRUG DESIGN & DISCOVERY, 2006, 3 (07) : 506 - 512
[42] Synthesis and evaluation of beta-hydroxytriazoles and related compounds as antitubercular agents
Menendez, Christophe
Mori, Giorgia
Maillot, Mathilde
Fabing, Isabelle
Carayon, Chantal
Orena, Beatrice Silvia
Pasca, Maria Rosalia
Voitenko, Zoia
Lherbet, Christian
Baltas, Michel
FRENCH-UKRAINIAN JOURNAL OF CHEMISTRY, 2015, 3 (01): : 82 - 96
[43] Synthesis of 4-position hydrophilic derivatives of thiolactomycin as antitubercular agents
Kim, P
Zhang, YM
Shenoy, G
Manjunatha, U
Boshoff, H
Nguyen, QA
Goodwin, M
Miller, D
White, S
Duncan, K
Rock, CO
Barry, CE
Dowd, CS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2759 - U2760
[44] Design, synthesis and biological evaluation of novel oxindole analogs as antitubercular agents
Khetmalis, Yogesh M.
Sangeetha, Guruvelli P., V
Chandu, Ala
Swati, Sankaranarayanan
Murugesan, Sankaranarayanan
Sharma, Vivek
Kumar, Muthyala M. K.
Kondapalli, Venkata G. C. S.
FUTURE MEDICINAL CHEMISTRY, 2023, 15 (15) : 1323 - 1342
[45] Synthesis of some new pyrrole derivatives as potential antimicrobial and antitubercular agents
Joshi, S. D.
Vagdevi, H. M.
Vaidya, V. P.
Gadaginamath, G. S.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 17 (02) : 165 - 168
[46] Novel Pyrimidines as Antitubercular Agents
Inoyama, Daigo
Paget, Steven D.
Russo, Riccardo
Kandasamy, Srinivasan
Kumar, Pradeep
Singleton, Eric
Occi, James
Tuckman, Margareta
Zimmerman, Matthew D.
Ho, Hsin Pin
Perryman, Alexander L.
Dartois, Veronique
Connell, Nancy
Freundlich, Joel S.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (03)
[47] SYNTHESES OF TRIAZOLOQUINOXALINES
Baashen, Mohammed A.
Abdel-Wahab, Bakr F.
El-Hiti, Gamal A.
HETEROCYCLES, 2016, 92 (11) : 1931 - 1952
[48] Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents
Liu, Lingfeng
Kong, Chengcheng
Fumagalli, Marco
Savkova, Karin
Xu, Yiwen
Huszar, Stanislav
Sammartino, Jose C.
Fan, Dongguang
Chiarelli, Laurent R.
Mikusova, Katarina
Sun, Zhaogang
Qiao, Chunhua
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 208
[49] Dimethyldithioimidocarbonates-mediated heterocyclizations: Synthesis of imidazolidines and benzheterocycles as potent antitubercular agents
Hegde, Vinayak S.
Kolavi, Gundurao D.
Lamani, Ravi S.
Khazi, Imtiyaz Ahmed M.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (04) : 911 - 920
[50] Design, synthesis and evaluation of oxime-functionalized nitrofuranylamides as novel antitubercular agents
Fan, Yi-Lei
Wu, Jian-Bing
Ke, Xing
Huang, Zhong-Ping
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (18) : 3064 - 3066

← 1 2 3 4 5 →