Synthesis of Triazoloquinoxalines as Antitubercular Agents

被引：8
|
作者：
Sekhar, Kondapalli Venkata Gowri Chandra [1 ]
Rao, Vajja Sambasiva [1 ]
Kumar, Dalip [2 ]
机构：
[1] BITS, Chem Grp, Hyderabad 500078, Andhra Pradesh, India
[2] BITS, Chem Grp, Pilani 333031, Rajasthan, India
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 08期
关键词：
Triazolo quinoxalines; Antitubercular; Iodobenzene diacetate; HETEROCYCLES; DERIVATIVES; ANTIMYCOBACTERIAL; ANTAGONISTS; IODINE; ROUTE;
D O I：
10.5012/bkcs.2011.32.8.2657
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, (1)H NMR, (13)C NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.
引用
收藏
页码：2657 / 2660
页数：4
相关论文
共 50 条
  • [31] SYNTHESIS OF SOME NEW THIOSEMICARBAZIDES AND THIOSEMICARBAZONES AS POSSIBLE ANTITUBERCULAR AND ANTIBACTERIAL AGENTS
    VANUGOPAL, D
    PANDYA, D
    NAIR, KB
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1989, 66 (05) : 344 - 345
  • [32] Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
    Yalcin-Ozkat, Gozde
    Ersan, Ronak H.
    Ulger, Mahmut
    Ulger, Seda T.
    Burmaoglu, Serdar
    Yildiz, Ilkay
    Algul, Oztekin
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (07): : 2667 - 2686
  • [33] Synthesis and Molecular Docking Study of Arylsulfanyl Pyrazolylpyrazoline Derivatives as Antitubercular Agents
    M. J. Zala
    J. J. Vora
    V. M. Khedkar
    Russian Journal of Organic Chemistry, 2021, 57 : 2054 - 2062
  • [34] Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
    Kar, Sidhartha S.
    Bhat, Varadaraj
    Rao, Praveen P. N.
    Shenoy, Vishnu P.
    Bairy, Indira
    Shenoy, G. Gautham
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 : 2299 - 2310
  • [35] Synthesis, screening and docking analysis of hispolon analogs as potential antitubercular agents
    Balaji, Neduri V.
    Babu, Bollikolla Hari
    Subbaraju, Gottumukkala V.
    Nagasree, Kurre Purna
    Kumar, Muthyala Murali Krishna
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (01) : 11 - 15
  • [36] Synthesis and Molecular Docking Study of Arylsulfanyl Pyrazolylpyrazoline Derivatives as Antitubercular Agents
    Zala, M. J.
    Vora, J. J.
    Khedkar, V. M.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 57 (12) : 2054 - 2062
  • [37] Synthesis of new C-dimethylated chalcones as potent antitubercular agents
    Rambabu Anandam
    Surender Singh Jadav
    Vasu Babu Ala
    Mohamed Jawed Ahsan
    Hari Babu Bollikolla
    Medicinal Chemistry Research, 2018, 27 : 1690 - 1704
  • [38] Synthesis of new C-dimethylated chalcones as potent antitubercular agents
    Anandam, Rambabu
    Jadav, Surender Singh
    Ala, Vasu Babu
    Ahsan, Mohamed Jawed
    Bollikolla, Hari Babu
    MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (06) : 1690 - 1704
  • [39] Synthesis and Biological Evaluation of N-Benzylindolylchalcone Analogs as Antitubercular Agents
    Joshi, Shivam
    Kawathekar, Neha
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023, 33 (03) : 349 - 354
  • [40] Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents
    Tewari, N
    Tiwari, VK
    Tripathi, RP
    Chaturvedi, V
    Srivastava, A
    Srivastava, R
    Shukla, PK
    Chaturvedi, AK
    Gaikwad, A
    Sinha, S
    Srivastava, BS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (02) : 329 - 332
12345