Synthesis of Triazoloquinoxalines as Antitubercular Agents

被引：8
|
作者：
Sekhar, Kondapalli Venkata Gowri Chandra [1 ]
Rao, Vajja Sambasiva [1 ]
Kumar, Dalip [2 ]
机构：
[1] BITS, Chem Grp, Hyderabad 500078, Andhra Pradesh, India
[2] BITS, Chem Grp, Pilani 333031, Rajasthan, India
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 08期
关键词：
Triazolo quinoxalines; Antitubercular; Iodobenzene diacetate; HETEROCYCLES; DERIVATIVES; ANTIMYCOBACTERIAL; ANTAGONISTS; IODINE; ROUTE;
D O I：
10.5012/bkcs.2011.32.8.2657
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1-aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, (1)H NMR, (13)C NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.
引用
收藏
页码：2657 / 2660
页数：4
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