Solubility, 1H-NMR, and molecular mechanics of mebendazole with different cyclodextrins

被引：9

作者：

Díaz, D ^{[1
]}

Bernad, MJB ^{[1
]}

Garcia-Mora, J ^{[1
]}

Llanos, CME ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan, Lab 213, Mexico City, DF, Mexico

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 01期

关键词：

D O I：

10.1081/DDC-100102151

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubility behavior and binding constants (K-ass) of mebendazole with alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) have been investigated in simulated intestinal juice by the Higuchi and Conners method. A(L) diagrams have been obtained. The equilibrium has also been studied in simulated gastric fluid with HP-beta-CD The phase solubility, H-1-NMR, and molecular mechanics studies revealed the formation of a 1 :1 complex.

引用

页码：111 / 115

页数：5