Solubility, 1H-NMR, and molecular mechanics of mebendazole with different cyclodextrins

被引：9
|
作者：
Díaz, D [1 ]
Bernad, MJB [1 ]
Garcia-Mora, J [1 ]
Llanos, CME [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan, Lab 213, Mexico City, DF, Mexico
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 01期
关键词：
D O I：
10.1081/DDC-100102151
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The solubility behavior and binding constants (K-ass) of mebendazole with alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) have been investigated in simulated intestinal juice by the Higuchi and Conners method. A(L) diagrams have been obtained. The equilibrium has also been studied in simulated gastric fluid with HP-beta-CD The phase solubility, H-1-NMR, and molecular mechanics studies revealed the formation of a 1 :1 complex.
引用
收藏
页码：111 / 115
页数：5
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