The Role of Wnt Signalling in Chronic Kidney Disease (CKD)

被引：28

作者：

Malik, Soniya A. ^{[1
]}

Modarage, Kavindiya ^{[1
]}

Goggolidou, Paraskevi ^{[1
]}

机构：

[1] Univ Wolverhampton, Fac Sci & Engn, Dept Biomed Sci & Physiol, Wulfruna St, Wolverhampton WV1 1LY, England

来源：

GENES | 2020年 / 11卷 / 05期

关键词：

Wnt signalling; polycystic kidney disease; nephronophthisis; beta-catenin; planar cell polarity signalling; PLANAR CELL POLARITY; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; MOLECULAR-CLONING; BETA-CATENIN; JOUBERT-SYNDROME; PROTEIN; URETERAL OBSTRUCTION; ABERRANT ACTIVATION; WIDE ASSOCIATION; GENE;

D O I：

10.3390/genes11050496

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of beta-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms.

引用

页数：19

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