The Role of Wnt Signalling in Chronic Kidney Disease (CKD)

被引：28
作者：
Malik, Soniya A. [1 ]
Modarage, Kavindiya [1 ]
Goggolidou, Paraskevi [1 ]
机构：
[1] Univ Wolverhampton, Fac Sci & Engn, Dept Biomed Sci & Physiol, Wulfruna St, Wolverhampton WV1 1LY, England
来源：
GENES | 2020年 / 11卷 / 05期
关键词：
Wnt signalling; polycystic kidney disease; nephronophthisis; beta-catenin; planar cell polarity signalling; PLANAR CELL POLARITY; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; MOLECULAR-CLONING; BETA-CATENIN; JOUBERT-SYNDROME; PROTEIN; URETERAL OBSTRUCTION; ABERRANT ACTIVATION; WIDE ASSOCIATION; GENE;
D O I：
10.3390/genes11050496
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of beta-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms.
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页数：19
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共 124 条
[11]   Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis [J].
Cnossen, Wybrich R. ;
te Morsche, Rene H. M. ;
Hoischen, Alexander ;
Gilissen, Christian ;
Chrispijn, Melissa ;
Venselaar, Hanka ;
Mehdi, Soufi ;
Bergmann, Carsten ;
Veltman, Joris A. ;
Drenth, Joost P. H. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (14) :5343-5348
[12]   Altered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy [J].
Cox, Sharon N. ;
Sallustio, Fabio ;
Serino, Grazia ;
Pontrelli, Paola ;
Verrienti, Raffaella ;
Pesce, Francesco ;
Torres, Diletta D. ;
Ancona, Nicola ;
Stifanelli, Patrizia ;
Zaza, Gianluigi ;
Schena, Francesco P. .
KIDNEY INTERNATIONAL, 2010, 78 (04) :396-407
[13]   Pathologic classification of focal segmental glomerulosclerosis: A working proposal [J].
D'Agati, VD ;
Fogo, AB ;
Bruijn, JA ;
Jennette, JC .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 43 (02) :368-382
[14]   Wnt/β-Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria [J].
Dai, Chunsun ;
Stolz, Donna B. ;
Kiss, Lawrence P. ;
Monga, Satdarshan P. ;
Holzman, Lawrence B. ;
Liu, Youhua .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (09) :1997-2008
[15]   The role of cilia in the pathogenesis of cystic kidney disease [J].
Dell, Katherine M. .
CURRENT OPINION IN PEDIATRICS, 2015, 27 (02) :212-218
[16]   The Genetics of IgA Nephropathy: An Overview from Western Countries [J].
Feehally, John ;
Barratt, Jonathan .
KIDNEY DISEASES, 2015, 1 (01) :33-41
[17]   Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome [J].
Frank, Valeska ;
den Hollander, Anneke I. ;
Bruechle, Nadina Ortiz ;
Zonneveld, Marijke N. ;
Nuernberg, Gudrun ;
Becker, Christian ;
Du Bois, Gabriele ;
Kendziorra, Heide ;
Roosing, Susanne ;
Senderek, Jan ;
Nuernberg, Peter ;
Cremers, Frans P. M. ;
Zerres, Klaus ;
Bergmann, Carsten .
HUMAN MUTATION, 2008, 29 (01) :45-52
[18]   Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation [J].
Fu, Hai-Di ;
Wang, Bei-Ke ;
Wan, Zi-Qiu ;
Lin, Heng ;
Chang, Mao-Lin ;
Han, Guang-Li .
JOURNAL OF MOLECULAR HISTOLOGY, 2016, 47 (05) :455-466
[19]   INFANTILE CHRONIC TUBULO-INTERSTITIAL NEPHRITIS WITH CORTICAL MICROCYSTS - VARIANT OF NEPHRONOPHTHISIS OR NEW DISEASE ENTITY [J].
GAGNADOUX, MF ;
BACRI, JL ;
BROYER, M ;
HABIB, R .
PEDIATRIC NEPHROLOGY, 1989, 3 (01) :50-55
[20]   Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans [J].
Genovese, Giulio ;
Friedman, David J. ;
Ross, Michael D. ;
Lecordier, Laurence ;
Uzureau, Pierrick ;
Freedman, Barry I. ;
Bowden, Donald W. ;
Langefeld, Carl D. ;
Oleksyk, Taras K. ;
Knob, Andrea L. Uscinski ;
Bernhardy, Andrea J. ;
Hicks, Pamela J. ;
Nelson, George W. ;
Vanhollebeke, Benoit ;
Winkler, Cheryl A. ;
Kopp, Jeffrey B. ;
Pays, Etienne ;
Pollak, Martin R. .
SCIENCE, 2010, 329 (5993) :841-845
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