Pregnancy-associated plasma protein A in non-cardiac conditions

被引：14

作者：

Iversen, Kasper Karmark ^{[1
]}

Teisner, Ane Sogaard ^{[2
]}

Teisner, Borge ^{[3
]}

Kliem, Anette ^{[4
]}

Bay, Morten ^{[1
]}

Kirk, Vibeke ^{[1
]}

Nielsen, Henrik ^{[2
]}

Boesgaard, Soren ^{[1
]}

Grande, Peer ^{[1
]}

Clernmensen, Peter ^{[1
]}

机构：

[1] Univ Copenhagen Hosp, Ctr Heart, Rigshosp, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen Hosp, Bispebjerg Hosp, DK-2100 Copenhagen, Denmark

[3] Gynaecol & Genet Ctr, London, England

[4] Univ So Denmark, Dept Immunol & Microbiol, Odense, Denmark

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 7-8期

关键词：

pregnancy-associated plasma protein A; specificity; coronary artery disease; non-cardiac conditions;

D O I：

10.1016/j.clinbiochem.2008.01.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease. Design and methods: PAPP-A was measured within 24 It following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes. Results: PAPP-A was detectable (>= 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A. Conclusion: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：548 / 553

页数：6

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