NK Cell Influence on the Outcome of Primary Epstein-Barr Virus Infection

被引：49

作者：

Chijioke, Obinna ^{[1
,2
]}

Landtwing, Vanessa ^{[2
]}

Muenz, Christian ^{[2
]}

机构：

[1] Univ Zurich Hosp, Inst Surg Pathol, Zurich, Switzerland

[2] Univ Zurich, Inst Expt Immunol, Viral Immunobiol, Zurich, Switzerland

来源：

FRONTIERS IN IMMUNOLOGY | 2016年 / 7卷

基金：

瑞士国家科学基金会;

关键词：

lytic EBV infection; NKG2D; DNAM-1; infectious mononucleosis; humanized mice; NATURAL-KILLER-CELLS; LINKED LYMPHOPROLIFERATIVE-DISEASE; HUMAN CYTOMEGALOVIRUS-INFECTION; EBV INFECTION; T-CELLS; PRIMARY IMMUNODEFICIENCY; HERPESVIRUS INFECTIONS; IMMUNE-RESPONSE; B-CELLS; MUTATIONS;

D O I：

10.3389/fimmu.2016.00323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The herpesvirus Epstein Barr virus (EBV) was discovered as the first human candidate tumor virus in Burkitt's lymphoma more than 50 years ago. Despite its strong growth transforming capacity, more than 90% of the human adult population carries this virus asymptomatically under near perfect immune control. The mode of primary EBV infection is in part responsible for EBV-associated diseases, including Hodgkin's lymphoma. It is, therefore, important to understand which circumstances lead to symptomatic primary EBV infection, called infectious mononucleosis (IM). Innate immune control of lytic viral replication by early -differentiated natural killer (NK) cells was found to attenuate IM symptoms and continuous loss of the respective NK cell subset during the first decade of life might predispose for IM during adolescence. In this review, we discuss the evidence that NK cells are involved in the immune control of EBV, mechanisms by which they might detect and control lytic EBV replication, and compare NK cell subpopulations that expand during different human herpesvirus infections.

引用

页数：7

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