Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract

被引：29
作者：
Donskey, CJ
Helfand, MS
Pultz, NJ
Rice, LB
机构：
[1] Case Western Reserve Univ, Sch Med, Louis Stokes Cleveland DVA Med Ctr, Res Serv,Infect Dis Sect 111 W, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Louis Stokes Cleveland DVA Med Ctr, Med Serv, Cleveland, OH 44106 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 01期
关键词：
D O I：
10.1128/AAC.48.1.326-328.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We examined the effect of subcutaneous fluoroquinolone antibiotic administration on persistence and density of vancomycin-resistant Enterococcus faecium stool colonization in mice. Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion.
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页码：326 / 328
页数：3
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