BMI1 promotes the progression of laryngeal squamous cell carcinoma

被引：35

作者：

Chen, Hui ^{[1
]}

Zhou, Liang ^{[1
]}

Wan, Guanglun ^{[2
]}

Dou, Tonghai ^{[3
]}

Tian, Jie ^{[4
]}

机构：

[1] Fudan Univ, Affiliated Eye & ENT Hosp, Dept Otolaryngol Head & Neck Surg, Shanghai 200433, Peoples R China

[2] Anhui Prov Hosp, Dept Otolaryngol Head & Neck Surg, Hefei, Peoples R China

[3] Fudan Univ, Sch Life Sci, Dept Microbiol, Shanghai 200433, Peoples R China

[4] Fudan Univ, Affiliated Eye & ENT Hosp, Cent Lab, Shanghai 200433, Peoples R China

来源：

ORAL ONCOLOGY | 2011年 / 47卷 / 06期

关键词：

BMI1; Laryngeal squamous cell carcinoma; Progression; Proliferation; Radiochemotherapy sensitization; BREAST-CANCER CELLS; STEM-CELLS; NASOPHARYNGEAL CARCINOMA; EPITHELIAL-CELLS; GENE-EXPRESSION; SELF-RENEWAL; AKT ACTIVITY; LUNG-CANCER; PROLIFERATION; SURVIVAL;

D O I：

10.1016/j.oraloncology.2011.03.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BMI1 is highly expressed in several malignant tumors, and its expression level is associated with tumor progression, proliferation, and prognosis. However, no published studies have examined the role of BMI1 in laryngeal squamous cell carcinoma (SCC). Expression of BMI1 in primary tumors was analyzed by immunofluorescence staining, real-time PCR, and Western blotting. BMI1 was knocked down, and proliferation, apoptosis, and cell cycle assays were performed. Sensitivity to radiochemotherapy was evaluated, and tumorigenicity assays were performed in vivo. BMI1 was highly expressed in laryngeal SCCs. BMI1 promoted cell proliferation and tumor progression, and inhibited apoptosis due to influences on the cell cycle. More importantly, BMI1 suppressed the sensitization of laryngeal Hep2 cells to radiochemotherapy. BMI1 is essential to maintain the proliferation and progression of laryngeal SCCs. Therefore, depletion of BMI1 may be a potential therapeutic option for cancer management. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：472 / 481

页数：10

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