Codon usage bias in radioresistant bacteria

被引：15
作者：
Dilucca, Maddalena [1 ]
Pavlopoulou, Athanasia [2 ]
Georgakilas, Alexandros G. [3 ]
Giansanti, Andrea [1 ,4 ]
机构：
[1] Sapienza Univ Rome, Phys Dept, Rome, Italy
[2] Dokuz Eyll Univ, Izmir Int Biomed & Genome Inst iBG Izmir, Izmir 35340, Turkey
[3] Natl Tech Univ Athens NTUA, Sch Appl Math & Phys Sci, Phys Dept, Athens, Greece
[4] INFN Roma1 Unit, Rome, Italy
来源：
GENE | 2020年 / 742卷
关键词：
Bacteria; Radioresistance; Gene; Codon bias; Protein interaction network; AMINO-ACID; NUCLEOTIDE COMPOSITION; GENE-EXPRESSION; GC-CONTENT; GENOME; DIVERSITY; EVOLUTION; SILENT;
D O I：
10.1016/j.gene.2020.144554
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The relationship between patterns of codon usage bias (CUB), the preferential usage of synonimous nucleotide triplets encoding the same amino acid, and radioresistance was investigated int he genomes of 16 taxonomically distinct radioresistant prokaryotic organisms and in a control set of 11 non-radioresistant bacteria. The radioresistant species were found to be strongly biased towards G and C in the third synonimous codon position. ENC and neutrality plots also sugest that CUB in radioresistant bacteria is mainly affected by mutational bias. Furthermore, the availability of tRNA gene copy number was analyzed and it was found that nine radioresistant species have the sam number of tRNA gene copies for each codon. This suggests that tRNA gene copies and codon bias co-evolved in a specific way in radioresistant species.
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页数：6
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