Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

被引：7
作者：
Sitnikova, Evgenia [1 ]
机构：
[1] Russian Acad Sci RAS, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia
来源：
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
基金：
俄罗斯基础研究基金会;
关键词：
spike-wave epilepsy; genetic rat model; slow wave sleep; intermediate stage of sleep; microarousals; ABSENCE EPILEPSY; INTERMEDIATE STAGE; ANIMAL-MODELS; DISCHARGES; SEIZURES; EEG; PATHOPHYSIOLOGY; PREDISPOSITION; TRANSITION; SPINDLES;
D O I：
10.3389/fneur.2021.766566
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8-10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit dysfunction, and this implies an intimate relationship between slow-wave EEG activity, sleep spindles, and SWDs. The present mini review summarizes relevant research on sleep-related disturbances associated with spike-wave epilepsy in WAG/Rij rats in the domain of slow-wave sleep EEG and microarousals. It also discusses enhancement of the intermediate stage of sleep. In general, sleep EEG studies provide important information about epileptogenic processes related to spike-wave epilepsy.
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页数：6
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