Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies

被引:81
作者
Lamotte, Christophe [1 ,2 ,3 ,4 ,5 ]
Iliescu, Catalina [6 ,7 ]
Libersa, Christian [2 ,4 ]
Gottrand, Frederic [2 ,4 ,5 ,8 ]
机构
[1] Ctr Hosp Univ, Ctr Invest Clin, F-59037 Lille, France
[2] Ctr Hosp Univ, Ctr Invest Clin, F-59000 Lille, France
[3] Ctr Hosp Univ, Serv Med Interne, F-59000 Lille, France
[4] Univ Lille Nord France, UDSL, Fac Med, F-59000 Lille, France
[5] INSERM, U995, IFR 114, F-59000 Lille, France
[6] Grp Hosp, Inst Catholique Iillois, Serv Pediat, F-59000 Lille, France
[7] Univ Lille Nord France, Univ Catholique Lille, F-59000 Lille, France
[8] Ctr Hosp Univ, Serv Pediat, F-59000 Lille, France
关键词
Intima-media thickness; Carotid artery; Childhood; Cardiovascular disease; Atherosclerosis; CARDIOVASCULAR RISK-FACTORS; TYPE-1; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; STAGE RENAL-DISEASE; FATTY LIVER-DISEASE; METABOLIC SYNDROME; OBESE CHILDREN; ENDOTHELIAL DYSFUNCTION; EARLY ATHEROSCLEROSIS; BLOOD-PRESSURE;
D O I
10.1007/s00431-010-1328-y
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Increased carotid intima-media thickness (cIMT) in adults may be caused by a childhood exposure to cardiovascular risk factors. We systematically reviewed observational studies to determine whether obesity, insulin-dependent diabetes mellitus (IDDM), dyslipidemia (DL), hypertension (HT), and chronic renal failure (CRF) are associated with increased cIMT in children and adolescent patients compared with control subjects. We performed a PubMed literature search from January 1986 to February 2010. Two reviewers separately verified the inclusion criteria of relevant studies for the objective of the review. The data extracted in the patient and control groups were sample size, age, gender, cIMT measurement methods, cIMT values, and statistical analysis results. From 348 citations, 65 cross-sectional studies (2 cited twice) with case-control design met the inclusion criteria: 26 in obesity, 14 in IDDM, 11 in DL, 8 in HT, and 8 in CRF. cIMT measurement protocols varied according to the studies, with measurements being performed on the common carotid artery in 65/67 cases and on the far wall in 57/67 cases. From the 67 studies cited, 22/26 reported a significantly increased cIMT in obese children and adolescents compared with the control group, 8/14 in IDDM patients, 10/11 in DL patients, 7/8 in HT patients, and 8/8 in CRF patients. Conclusion: Despite the heterogeneity of ultrasound measurement methods, cIMT was significantly increased in 55 out of the 67 cited studies, confirming early vascular damages in pediatric populations with an increased future risk for vascular diseases.
引用
收藏
页码:719 / 729
页数:11
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