Visible light driven metal- free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1( 2H)- one+

被引：15

作者：

Zou, Shuai ^{[1
]}

Geng, Shu ^{[1
]}

Chen, Lina ^{[1
]}

Wang, Haitao ^{[1
]}

Huang, Feng ^{[1
]}

机构：

[1] State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

N-RADICAL CASCADE; PHOTOREDOX CATALYSIS; ELECTRON-TRANSFER; EOSIN Y; TRIFLUOROMETHYLATION; HYDROAMINATION; CONSTRUCTION; ALKYLATION; GENERATION; HYDRAZONES;

D O I：

10.1039/c8ob02560f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A visible-light metal-free photocatalytic synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one derivatives under mild conditions in moderate to good yields is described. EosinY Na, an organic dye, which is of low cost and has good availability, is used as the photocatalyst. A wide range of substrates are tolerated and the gram-scale reaction can also proceed smoothly. Mechanistic studies indicate that a plausible free radical process is proposed.

引用

页码：380 / 387

页数：8

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