68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer

被引：8
作者：
Zacho, Helle D. [1 ,2 ,3 ]
Pedersen, Sine H. [4 ]
Petersen, Astrid [4 ]
Petersen, Lars J. [1 ,2 ,3 ]
机构：
[1] Aalborg Univ Hosp, Dept Nucl Med, Hobrovej 18-22,Postboks 365, DK-9100 Aalborg, Denmark
[2] Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark
[3] Aalborg Univ, Dept Clin Med, Aalborg, Denmark
[4] Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark
来源：
CLINICAL NUCLEAR MEDICINE | 2020年 / 45卷 / 01期
关键词：
Ga-68-PSMA; PET/CT; prostate cancer; PSMA expression; urothelial cancer; F-18-DCFPYL PET/CT; PROSTATE; PSMA;
D O I：
10.1097/RLU.0000000000002720
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Ga-68-PSMAPET/CT has become awell-established imagingmodality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, Ga-68-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent Ga-68-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The Ga-68-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.
引用
收藏
页码：E43 / E45
页数：3
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