5-Hydroxymethylcytosine: A new player in brain disorders?

被引：53

作者：

Cheng, Ying ^{[1
,2
]}

Bernstein, Alison ^{[1
]}

Chen, Dahua ^{[2
]}

Jin, Peng ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

[2] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China

来源：

EXPERIMENTAL NEUROLOGY | 2015年 / 268卷

基金：

美国国家卫生研究院;

关键词：

5-Methylcytosine (5mC); 5-Hydroxymethylcytosine (5hmC); Neurodevelopmental disorder; Neurodegenerative disease; Ten-eleven translocation (Tet) protein; EMBRYONIC STEM-CELLS; DNA METHYLTRANSFERASES DNMT3A; ALCOHOL SPECTRUM DISORDERS; ALZHEIMERS-DISEASE; RETT-SYNDROME; HUNTINGTONS-DISEASE; FRAGILE-X; TREMOR/ATAXIA SYNDROME; MAMMALIAN DEVELOPMENT; TET PROTEINS;

D O I：

10.1016/j.expneurol.2014.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

5-Hydroxymethylcytosine (5hmC), a novel modified cytosine, is oxidized from 5-methylcytosine (5mC) by the ten-eleven translocation (Tet) protein family. The specific distribution of 5hmC in mammalian brain and its roles in gene regulation suggest that 5hmC is important in brain development. 5hmC may also contribute to the mechanisms underlying neurological diseases. Here, we summarize the current knowledge of 5hmC, with an emphasis on its roles in neurodevelopmental and neurodegenerative disorders. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：3 / 9

页数：7

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