EXAMINATION OF THE STRUCTURE OF AGARICINIC ACID USING 1H AND 13C NMR SPECTROSCOPY

被引：7

作者：

Airapetova, A. Yu. ^{[1
]}

Gavrilin, M. V. ^{[1
]}

Dmitriev, A. B. ^{[1
]}

Mezenova, T. D. ^{[1
]}

机构：

[1] Pyatigorsk State Pharmaceut Acad, Pyatigorsk, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 09期

关键词：

agaricinic acid; Fomitopsis officinalis; extraction; structure; NMR spectrum;

D O I：

10.1007/s11094-010-0505-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Agaricinic acid was extracted from the carpophore of Fomitopsis officinalis (Vill. Bond. et Sing). Its structure was established by H-1 and C-13 NMR spectroscopy and comparison to a standard sample (Sigma-Aldrich). The extraction was carried out using ethanol. The obtained extract was evaporated, cooled (-5 degrees C), and purified by ether. The structure of unbranched alkyl radicals was determined using their proton spectrum. The C-13 NMR spectrum and two-dimensional {C-13, H-1} correlation diagram showed the presence of a hydroxyl (second quaternary C atom) and three types of carboxy groups (first, second, and third C atoms). The spectrum of the extracted sample is identical to that of the standard sample of agaricinic acid.

引用

页码：510 / 513

页数：4