Carbonic anhydrase IX inhibitors: fluorescent sulfonamides as therapeutic and diagnostic agents

被引：3
|
作者：
Winum, Jean-Yves [1 ]
机构：
[1] Ecole Natl Super Chim Montpellier, Inst Biomol Max Mousseron, Bat Rech Max Mousseron, CNRS,UM1,UM2,UMR 5247, F-34296 Montpellier, France
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 11期
关键词：
anticancer agents; CA IX; carbonic anhydrase IX; hypoxic tumour; sulfonamide;
D O I：
10.1517/13543776.17.11.1393
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This patent application discloses a novel class of strong carbonic anhydrase IX inhibitors bearing fluorescent tails. These compounds are claimed for use as therapeutic and imaging agents of hypoxic tumours, which are poorly responsive to classical chemo- and radiotherapies and constitute a novel strategy for cancer management.
引用
收藏
页码：1393 / 1396
页数：4
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