Cardiac Z-disc Signaling Network

被引：130

作者：

Frank, Derk ^{[1
]}

Frey, Norbert ^{[1
]}

机构：

[1] Univ Kiel, D-24105 Kiel, Germany

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 12期

关键词：

INTEGRIN-LINKED KINASE; MUSCLE LIM PROTEIN; MECHANICAL STRETCH SENSOR; ACTIN CAPPING PROTEIN; SARCOMERIC Z-DISC; DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; GENE-EXPRESSION; HEART-FAILURE;

D O I：

10.1074/jbc.R110.174268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the last 15 years, the perception of the cardiac z-disc has undergone substantial changes. Initially viewed as a structural component at the lateral boundaries of the sarcomere, the cardiac z-disc has increasingly become recognized as a nodal point in cardiomyocyte signal transduction and disease. This minireview thus focuses on novel components and recent developments in z-disc biology and their role in cardiac signaling and disease.

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收藏

页码：9897 / 9904

页数：8

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