A novel dual-site ICT/AIE fluorescent probe for detecting hypochlorite and polarity in living cells

被引：15
作者：
Li, Mingrui [1 ]
Fang, Wangwang [2 ]
Wang, Bowei [1 ,3 ,4 ]
Du, Yuchao [1 ]
Hou, Yuqing [5 ]
Chen, Ligong [1 ,3 ,4 ]
Cui, Siqian [1 ]
Li, Yang [1 ,3 ]
Yan, Xilong [1 ,3 ,4 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China
[2] Shaoxing Xingxin New Mat Co Ltd, Shangyu City 312369, Zhejiang, Peoples R China
[3] Tianjin Engn Res Ctr Funct Fine Chem, Tianjin, Peoples R China
[4] Tianjin Univ, Zhejiang Shaoxing Inst, Shaoxing, Zhejiang, Peoples R China
[5] Zhejiang Lonsen Grp Co Ltd, Shaoxing 312300, Zhejiang, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 45期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
AGGREGATION-INDUCED EMISSION; MYELOPEROXIDASE; HCLO; ACID; SELECTIVITY; OXIDATION; CRUMBS; MODEL; DOTS; DYES;
D O I：
10.1039/d1nj03558d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel dual-site fluorescent probe (CTPA) was rationally designed and synthesized for the detection of hypochlorite (ClO-) and polarity. CTPA displayed an excellent sensitivity (LOD = 11.9 nM) and selectivity as well as a rapid response within 30 s to ClO-. Besides, it is worth noting that the introduction of triphenylamine into the D-pi-A structure is beneficial to monitor the fluctuation of polarity. It was found that CTPA could respond to polarity fluctuation via the two channels of fluorescence intensity and maximum emission wavelength. In addition, CTPA exhibited low toxicity and was successfully applied to detect the endogenous and exogenous ClO- in HeLa cells and HIN-3T3 cells and distinguish the two kinds of cells by ClO- and polarity. Furthermore, this work provides a promising strategy for the development of dual-site fluorescent probes aiming at the detection of biologically relevant analytes by the collocation of recognizing groups.
引用
收藏
页码：21406 / 21414
页数：9
相关论文
共 50 条
  • [1] The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth
    Andersen, Ditte S.
    Colombani, Julien
    Palmerini, Valentina
    Chakrabandhu, Krittalak
    Boone, Emilie
    Roethlisberger, Michael
    Toggweiler, Janine
    Basler, Konrad
    Mapelli, Marina
    Hueber, Anne-Odile
    Leopold, Pierre
    [J]. NATURE, 2015, 522 (7557) : 482 - +
  • [2] An imidazole derivative-based chemodosimeter for Zn2+ and Cu2+ ions through "ON-OFF-ON" switching with intracellular Zn2+ detection
    Ansari, Shagufi N.
    Saini, Anoop K.
    Kumari, Pratibha
    Mobin, Shaikh M.
    [J]. INORGANIC CHEMISTRY FRONTIERS, 2019, 6 (03) : 736 - 745
  • [3] An AIE and ICT based NIR florescent probe for cysteine and homocysteine
    Bu, Lulu
    Chen, Junqin
    Wei, Xiaodong
    Li, Xin
    Agren, Hans
    Xie, Yongshu
    [J]. DYES AND PIGMENTS, 2017, 136 : 724 - 731
  • [4] The Crumbs complex: from epithelial-cell polarity to retinal degeneration
    Bulgakova, Natalia A.
    Knust, Elisabeth
    [J]. JOURNAL OF CELL SCIENCE, 2009, 122 (15) : 2587 - 2596
  • [5] Development of H2S and HClO dual-responsive fluorescent probe for cancer recognition
    Chen, Yu
    Lim, Ja-Yun
    Wu, Xiang Hua
    Heo, June Seok
    Yuan, Fengying
    Zhang, Jun Feng
    Yoon, Dae Wui
    Ren, Wen Xiu
    [J]. DYES AND PIGMENTS, 2021, 195
  • [6] A highly sensitive and selective hypochlorite fluorescent probe based on oxidation of hydrazine via free radical mechanism
    Cheng, Tanyu
    Zhao, Junwei
    Wang, Ziyun
    An, Juzeng
    Xu, Yufang
    Qian, Xuhong
    Liu, Guohua
    [J]. DYES AND PIGMENTS, 2016, 126 : 218 - 223
  • [7] Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength
    Cheng, Wei
    Xue, Xuqi
    Gan, Lu
    Jin, Peng
    Zhang, Baoxin
    Guo, Menghuan
    Si, Jing
    Du, Hongying
    Chen, Hongli
    Fang, Jianguo
    [J]. ANALYTICA CHIMICA ACTA, 2021, 1156
  • [8] Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications
    Cui, Jingjing
    Yao, Yuhua
    Chen, Cong
    Huang, Rui
    Zhang, Weibing
    Qian, Junhong
    [J]. CHINESE CHEMICAL LETTERS, 2019, 30 (05) : 1071 - 1074
  • [9] Dual-site fluorescent probe for multi-response detection of ClO- and H2O2 and bio-imaging
    Du, Yuchao
    Wang, Bowei
    Jin, Di
    Li, Mingrui
    Li, Yang
    Yan, Xilong
    Zhou, Xueqin
    Chen, Ligong
    [J]. ANALYTICA CHIMICA ACTA, 2020, 1103 (1103) : 174 - 182
  • [10] A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis
    Fan, Li
    Wang, Xiaodong
    Ge, Jinyin
    Li, Feng
    Wang, Xiao
    Wang, Juanjuan
    Shuang, Shaomin
    Dong, Chuan
    [J]. CHEMICAL COMMUNICATIONS, 2019, 55 (32) : 4703 - 4706
12345