CT characteristics of resolving ground-glass opacities in a lung cancer screening programme

被引:45
作者
Felix, L.
Serra-Tosio, G.
Lantuejoul, S. [2 ,3 ]
Timsit, J. F. [3 ]
Moro-Sibilot, D. [3 ,4 ]
Brambilla, C. [3 ,4 ]
Ferretti, G. R. [1 ,3 ]
机构
[1] Univ Grenoble 1, CHU Grenoble, Serv Cent Radiol & Imagerie Med, Clin Univ Radiol & Imagerie Med, F-38043 Grenoble 09, France
[2] Univ Grenoble 1, CHU Grenoble, Dept Anat Pathol, F-38043 Grenoble 09, France
[3] A Bonniot Inst, INSERM, U823, La Tronche, France
[4] Univ Grenoble 1, CHU Grenoble, Clin Univ Pneumol, F-38043 Grenoble 09, France
关键词
Pulmonary nodule; Ground-glass attenuation; Thoracic CT; High-resolution MDCT; Follow-up CT; THIN-SECTION CT; HIGH-RESOLUTION CT; DOSE HELICAL CT; PULMONARY NODULES; SMALL ADENOCARCINOMA; FOLLOW-UP; POPULATION; BENIGN; ATTENUATION;
D O I
10.1016/j.ejrad.2009.09.008
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer. Material and methods: 280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n = 83), head and neck cancer history (n = 63), symptomatic (n = 88) and asymptomatic (n = 46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests. Results: A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p = 0.006), polygonal in shape (p = 0.02), mixed (p = 0.003) and larger (p < 0.0001) than non-resolving localized GGOs. Conclusion: Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:410 / 416
页数:7
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