Catalytic asymmetric alkylation of aldehydes with Grignard reagents

被引：70

作者：

Muramatsu, Yusuke ^{[1
]}

Harada, Toshiro ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Chem & Mat Technol, Sakyo Ku, Kyoto 6068585, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 06期

关键词：

alkylation; asymmetric catalysis; asymmetric synthesis; Grignard reaction; titanium;

D O I：

10.1002/anie.200704963

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Added benefits: Grignard reagents can be employed in the asymmetric alkylation of aldehydes by using a titanium(IV) catalyst derived from binol in the presence of excess titanium tetraisopropoxide (see scheme). The reaction proceeds with a low catalyst loading (2 mol%) and exhibits high enantioselectivity for both aromatic and unsaturated aldehydes and for both alkyl and aryl Grignard reagents. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1088 / 1090

页数：3

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