Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

被引：81

作者：

Brett, PJ ^{[1
]}

Woods, DE ^{[1
]}

机构：

[1] UNIV CALGARY,HLTH SCI CTR,FAC MED,DEPT MICROBIOL & INFECT DIS,CALGARY,AB T2N 4N1,CANADA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 07期

关键词：

D O I：

10.1128/IAI.64.7.2824-2828.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

引用

页码：2824 / 2828

页数：5

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