Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

被引：79
作者：
Brett, PJ [1 ]
Woods, DE [1 ]
机构：
[1] UNIV CALGARY,HLTH SCI CTR,FAC MED,DEPT MICROBIOL & INFECT DIS,CALGARY,AB T2N 4N1,CANADA
来源：
INFECTION AND IMMUNITY | 1996年 / 64卷 / 07期
关键词：
D O I：
10.1128/IAI.64.7.2824-2828.1996
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.
引用
收藏
页码：2824 / 2828
页数：5
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