LOW HEMOGLOBIN LEVELS DURING NORMOVOLEMIA ARE ASSOCIATED WITH ELECTROCARDIOGRAPHIC CHANGES IN PIGS

被引：5

作者：

Scheller, Bertram ^{[1
]}

Pipa, Gordon ^{[2
,3
]}

Kertscho, Harry ^{[1
]}

Lauscher, Patrick ^{[1
]}

Ehrlich, Joachim ^{[4
]}

Habler, Oliver ^{[5
]}

Zacharowski, Kai ^{[1
]}

Meier, Jens ^{[1
]}

机构：

[1] Univ Hosp Frankfurt, Clin Anesthesiol Intens Care Med & Pain Therapy, D-60590 Frankfurt, Germany

[2] Max Planck Inst Brain Res, Dept Neurophysiol, D-60496 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Frankfurt Inst Adv Studies, Frankfurt, Germany

[4] Univ Hosp Frankfurt, Dept Med, Div Cardiol, D-60590 Frankfurt, Germany

[5] Hosp Nordwest, Clin Anesthesiol Intens Care Med & Pain Therapy, Frankfurt, Germany

来源：

SHOCK | 2011年 / 35卷 / 04期

关键词：

ECG; normovolemia; anemia; QT prolongation; T wave; hemoglobin; QT INTERVAL; CARDIOVASCULAR MORTALITY; OXYGEN DELIVERY; SUDDEN-DEATH; HEART; PROLONGATION; RISK; HEMODILUTION; DISPERSION; INCREASES;

D O I：

10.1097/SHK.0b013e3181f6aa44

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We studied whether low hemoglobin concentrations during normovolemia change the myocardial electrical current (electrocardiogram) in a pig model. Normovolemic anemia was achieved by stepwise replacing blood with colloids (hydroxyethyl starch 6%). We measured the length of the PQ-, QT-, QTc, and the ST interval as well as the amplitude of the Q wave and T wave at hemoglobin concentrations of 9.5, 8.0, 5.5, 3.8, and 3.3 g.dL(-1). Normovolemic anemia is accompanied by a gradual prolongation of the QT and QTc interval and a reduction in the amplitude of the T wave. The QRS complex is partly diminished in amplitude. Results were verified performing a time-frequency analysis on single heartbeats. During severe anemia and normovolemia, electrocardiographic changes can be detected. Further investigations are warranted to elucidate whether these changes indicate myocardial hypoxia.

引用

页码：375 / 381

页数：7

共 50 条

[31] Comparison of quantifiable electrocardiographic changes associated with severe hyperkalemia [J].

Tsai, Christina ;

Patel, Hiren ;

Horbal, Piotr ;

Dickey, Sierra ;

Peng, Yuanzun ;

Nwankwo, Eugene ;

Hicks, Hunter ;

Chen, Guanhua ;

Hussein, Ahmed ;

Gopinathannair, Rakesh ;

Mar, Philip L. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2023, 391

[32] Electrocardiographic changes associated with dehydration in rabbits (Oryctolagus cuniculus) [J].

Kour, Juneet ;

Ahmed, Jafrin Ara ;

Nashiruddullah, Nawab .

INDIAN JOURNAL OF ANIMAL RESEARCH, 2016, 50 (06) :1023-1026

[33] Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study [J].

Fanxia Meng ;

Shixin Zhang ;

Jie Yu ;

Yi Chen ;

Lunjie Luo ;

Fangping He ;

Ruili Wei ;

Huaiwu Yuan ;

Renjie Ji ;

Hanfeng Chen ;

Benyan Luo .

Translational Stroke Research, 2020, 11 :890-899

[34] Altered Metabolism of Blood Manganese Is Associated with Low Levels of Hemoglobin in Patients with Chronic Kidney Disease [J].

Kim, Minyoung ;

Koh, Eun Sil ;

Chung, Sungjin ;

Chang, Yoon Sik ;

Shin, Seok Joon .

NUTRIENTS, 2017, 9 (11)

[35] ELECTROCARDIOGRAPHIC CHANGES DURING CORONARY STENT PLACEMENT IN SWINE [J].

Simeonova, Galina ;

Dinev, D. ;

Roydev, R. .

ACTA VETERINARIA-BEOGRAD, 2010, 60 (5-6) :479-486

[36] Acute electrocardiographic changes during smoking: an observational study [J].

Ramakrishnan, Sivasubramanian ;

Bhatt, Kinjal ;

Dubey, Akhilesh K. ;

Roy, Ambuj ;

Singh, Sandeep ;

Naik, Nitish ;

Seth, Sandeep ;

Bhargava, Balram .

BMJ OPEN, 2013, 3 (04)

[37] Lower Hemoglobin Levels Are Associated with Acute Seizures in Patients with Ruptured Cerebral Aneurysms [J].

Wang, Deng-Liang ;

Lin, Peng ;

Lin, Zhang-Ya ;

Zheng, Shu-Fa ;

Shang-Guan, Huang-Cheng ;

Kang, De-Zhi ;

Chen, Guo-Rong ;

Zhang, Yi-Bin ;

Wen, Chun-Shui ;

Lin, Yuan-Xiang ;

Yao, Pei-Sen .

WORLD NEUROSURGERY, 2019, 127 :E1237-E1241

[38] CFTR Modulator Use Is Associated with Higher Hemoglobin Levels in Individuals with Cystic Fibrosis [J].

Gifford, Alex H. ;

Heltshe, Sonya L. ;

Goss, Christopher H. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2019, 16 (03) :331-340

[39] Relevance of oxygen in radiation oncology - Mechanisms of action, correlation to low hemoglobin levels [J].

Molls, M ;

Stadler, P ;

Becker, A ;

Feldmann, HJ ;

Dunst, J .

STRAHLENTHERAPIE UND ONKOLOGIE, 1998, 174 :13-16

[40] Low hemoglobin is associated with increased serum levels of vascular endothelial growth factor (VEGF) in cancer patients -: Does anemia stimulate angiogenesis? [J].

Dunst, J ;

Pigorsch, S ;

Hänsgen, G ;

Hintner, I ;

Lautenschläger, C ;

Becker, A .

STRAHLENTHERAPIE UND ONKOLOGIE, 1999, 175 (03) :93-96

← 1 2 3 4 5 →