LOW HEMOGLOBIN LEVELS DURING NORMOVOLEMIA ARE ASSOCIATED WITH ELECTROCARDIOGRAPHIC CHANGES IN PIGS

被引：5

作者：

Scheller, Bertram ^{[1
]}

Pipa, Gordon ^{[2
,3
]}

Kertscho, Harry ^{[1
]}

Lauscher, Patrick ^{[1
]}

Ehrlich, Joachim ^{[4
]}

Habler, Oliver ^{[5
]}

Zacharowski, Kai ^{[1
]}

Meier, Jens ^{[1
]}

机构：

[1] Univ Hosp Frankfurt, Clin Anesthesiol Intens Care Med & Pain Therapy, D-60590 Frankfurt, Germany

[2] Max Planck Inst Brain Res, Dept Neurophysiol, D-60496 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Frankfurt Inst Adv Studies, Frankfurt, Germany

[4] Univ Hosp Frankfurt, Dept Med, Div Cardiol, D-60590 Frankfurt, Germany

[5] Hosp Nordwest, Clin Anesthesiol Intens Care Med & Pain Therapy, Frankfurt, Germany

来源：

SHOCK | 2011年 / 35卷 / 04期

关键词：

ECG; normovolemia; anemia; QT prolongation; T wave; hemoglobin; QT INTERVAL; CARDIOVASCULAR MORTALITY; OXYGEN DELIVERY; SUDDEN-DEATH; HEART; PROLONGATION; RISK; HEMODILUTION; DISPERSION; INCREASES;

D O I：

10.1097/SHK.0b013e3181f6aa44

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We studied whether low hemoglobin concentrations during normovolemia change the myocardial electrical current (electrocardiogram) in a pig model. Normovolemic anemia was achieved by stepwise replacing blood with colloids (hydroxyethyl starch 6%). We measured the length of the PQ-, QT-, QTc, and the ST interval as well as the amplitude of the Q wave and T wave at hemoglobin concentrations of 9.5, 8.0, 5.5, 3.8, and 3.3 g.dL(-1). Normovolemic anemia is accompanied by a gradual prolongation of the QT and QTc interval and a reduction in the amplitude of the T wave. The QRS complex is partly diminished in amplitude. Results were verified performing a time-frequency analysis on single heartbeats. During severe anemia and normovolemia, electrocardiographic changes can be detected. Further investigations are warranted to elucidate whether these changes indicate myocardial hypoxia.

引用

页码：375 / 381

页数：7

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