Radiotherapy: An immune response modifier for immuno-oncology

被引:55
作者
De Martino, Mara [1 ]
Daviaud, Camille [1 ]
Vanpouille-Box, Claire [1 ,2 ]
机构
[1] Weill Cornell Med, Dept Radiat Oncol, 1300 York Ave,Box 169, New York, NY 10065 USA
[2] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA
关键词
Radiotherapy; Adjuvanticity; Immunosuppression; Type I interferon; Nucleic acid sensing; Tumor microenvironment; ENDOTHELIAL GROWTH-FACTOR; ACTIVATION PROTEIN-ALPHA; REGULATORY T-CELLS; TGF-BETA; RIG-I; ANTITUMOR IMMUNITY; ACTIVIN-A; TUMOR MICROENVIRONMENT; STROMAL CELLS; FREE-RADICALS;
D O I
10.1016/j.smim.2021.101474
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The ability of radiotherapy to enhance antigenicity and adjuvanticity of an irradiated tumor has stimulated the interest for its combination with immuno-oncology agents. However, radiotherapy often generates multiple layers of host responses which likely depends on the tumor biology, the immune cell infiltration and the induction of immunosuppressive signals post radiotherapy. Consequently, translation of preclinical findings to the clinic is more convoluted than anticipated which underscore the need to decipher molecular and cellular mechanisms elicited by radiotherapy. Here we review pro-inflammatory and immunosuppressive mechanisms triggered by radiotherapy that impact the outcome of antigen specific T cell killing and discuss how radiation-induced immunostimulatory mechanisms can be exploited to reactivate the host's immune system, especially in the context of immunotherapy.
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页数:7
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