Individual and Joint Action of Environmental Factors and Risk of MS

被引：44

作者：

van der Mei, I. A. F. ^{[1
]}

Simpson, S., Jr. ^{[1
]}

Stankovich, J. ^{[1
]}

Taylor, B. V. ^{[1
]}

机构：

[1] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7000, Australia

来源：

NEUROLOGIC CLINICS | 2011年 / 29卷 / 02期

关键词：

multiple sclerosis; Environmental factors; Gene-environment interaction; Review; Cause; EPSTEIN-BARR-VIRUS; CENTRAL-NERVOUS-SYSTEM; HEPATITIS-B VACCINATION; VITAMIN-D DEFICIENCY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; 3 AUSTRALIAN CITIES; MULTIPLE-SCLEROSIS; 1,25-DIHYDROXYVITAMIN D-3; CIGARETTE-SMOKING; INFECTIOUS-MONONUCLEOSIS;

D O I：

10.1016/j.ncl.2010.12.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this review, the evidence for the leading environmental and lifestyle factors thought to play a role in multiple sclerosis (MS) onset, including Epstein-Barr virus, sun exposure or vitamin D, and smoking, will be discussed. The Causal Pie Model is used as a conceptual framework to understand the causation. Given that no single factor leads to the development of MS, the joint action or interaction of these factors, along with genetic factors, most particularly the HLA-DR15*1501 genotype, is a primary focus.

引用

页码：233 / +

页数：24

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