Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells

被引：52
|
作者：
Zhang, Yi [1 ]
Xu, Xiaoman [2 ]
He, Ping [1 ]
机构：
[1] China Med Univ, Dept Geriatr, Shengjing Hosp, Shengjing 110004, Liaoning, Peoples R China
[2] China Med Univ, Dept Resp Med, Shengjing Hosp, Shengjing 110004, Liaoning, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2011年 / 4卷 / 01期
关键词：
tubeinioside-1; apoptosis; A549 human lung cancer cell line; CYCLOOXYGENASE-2; EXPRESSION; PANCREATIC-CANCER; MITOCHONDRIA; STATISTICS; ANTITUMOR;
D O I：
10.3892/mmr.2010.379
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Plant materials are a great source of cancer chemotherapeutic agents. Tubeimoside-1 (TBMS1) is a triterpenoid saponin extracted from the tubers of Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae), a widely prescribed traditional Chinese medicinal plant that is used for its antiviral and anti-inflammatory properties. The present study was conducted to investigate the effects of TBMS1 on the growth and apoptosis of human lung cancer A549 cells. TBMS1 inhibited the proliferation of the cells in a dose- and time-dependent manner. Apoptosis was confirmed by flow cytometry, fluorescence microscopy and transmission electron microscopy. TBMS1 treatment induced apoptosis by decreasing the expression of Bcl-2 and increasing the expression of Bax in the A549 cells. Inhibition of COX-2 was also observed after treating the cells with TBMS1. TBMS1 may prove to be a useful approach for the chemotherapy of lung cancer.
引用
收藏
页码：25 / 29
页数：5
相关论文
共 50 条
  • [1] Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2
    Li, Xia
    Li, Fang
    Wang, Fangfang
    Li, Jinfeng
    Lin, Cunzhi
    Du, Jianxin
    ONCOTARGETS AND THERAPY, 2018, 11 : 2981 - 2989
  • [2] β-caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
    Shabana, Sameh M.
    Gad, Nahla S.
    Othman, Azza I.
    Mohamed, Aly Fahmy
    El-Missiry, Mohamed Amr
    MEDICAL ONCOLOGY, 2023, 40 (07)
  • [3] β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
    Sameh M. Shabana
    Nahla S. Gad
    Azza I. Othman
    Aly Fahmy Mohamed
    Mohamed Amr El-Missiry
    Medical Oncology, 40
  • [4] Ouabain inhibits RAW264.7 cells proliferation and induces apoptosis via Bcl-2 and bax expression
    Luo, Yi
    Qin, Hongxia
    Zhao, Lin
    Jin, Long
    Jiang, Anan
    Li, Xuewei
    Li, Mingzhou
    Wang, Xun
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 31 (05) : 1997 - 2003
  • [5] Tubeimoside-1 induces glioma apoptosis through regulation of Bax/Bcl-2 and the ROS/Cytochrome C/Caspase-3 pathway
    Jia, Geng
    Wang, Qiang
    Wang, Rong
    Deng, Danni
    Xue, Lian
    Shao, Naiyuan
    Zhang, Yi
    Xia, Xiwei
    Zhi, Feng
    Yang, Yilin
    ONCOTARGETS AND THERAPY, 2015, 8 : 303 - 309
  • [6] Chamaejasmine induces apoptosis in human non-small-cell lung cancer A549 cells through increasing the Bax/Bcl-2 ratio, caspase-3 and activating the Fas/FasL
    Wang, Jinan
    Li, Xiuwei
    MINERVA MEDICA, 2021, 112 (03) : 413 - 415
  • [7] N-(2-hydroxyphenyl) acetamide induces apoptosis of brain cancer cells by increasing Bax/Bcl-2 ratio
    Hanif, Farina
    Perveen, Kahkashan
    Simjee, Shabana Usman
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2014, 70 (03) : 321 - 321
  • [8] Gypenosides induces apoptosis in human non-small-cell lung cancer A549 cells via increasing the Bax/Bcl-2 ratio, caspase-3 and suppressing the NF-κB
    Li, Xiaoli
    Liang, Liming
    Yu, Dee
    Fu, Hongdu
    Mo, Zhanduan
    Wang, Yujuan
    PANMINERVA MEDICA, 2021, 63 (01) : 94 - 95
  • [9] Effect of magnetosomes on cell proliferation, apoptosis induction and expression of Bcl-2 in the human lung cancer cell line A549
    Novakova, Zuzana Varchulova
    Gasparova, Iveta
    Krajciova, Lubica
    Molcan, Matus
    Varga, Ivan
    Timko, Milan
    Danisovic, Lubos
    BIOLOGIA, 2017, 72 (05) : 554 - 560
  • [10] Effect of magnetosomes on cell proliferation, apoptosis induction and expression of Bcl-2 in the human lung cancer cell line A549
    Zuzana Varchulova Novakova
    Iveta Gasparova
    Lubica Krajciova
    Matus Molcan
    Ivan Varga
    Milan Timko
    Lubos Danisovic
    Biologia, 2017, 72 : 554 - 560
12345