DNA Binding, amelioration of oxidative stress, and molecular docking study of Zn(II) metal complex of a new Schiff base ligand

被引：46

作者：

Mishra, Dipu Kumar ^{[1
]}

Singha, Uttam Kumar ^{[1
]}

Das, Ananya ^{[1
]}

Dutta, Somit ^{[2
]}

Kar, Pallab ^{[3
]}

Chakraborty, Arnab ^{[3
]}

Sen, Arnab ^{[3
]}

Sinha, Biswajit ^{[1
]}

机构：

[1] Univ North Bengal, Dept Chem, Darjeeling, India

[2] Univ North Bengal, Dept Zool, Cellular Immunol Lab, Siliguri, India

[3] Univ North Bengal, Dept Bot, Mol Genet Lab, Siliguri, India

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2018年 / 71卷 / 14期

关键词：

3; 3-Methylenedianiline; 2-Hydroxy-5-nitro-benzaldehyde; Zn(II) Complex; DNA Cleavage; molecular docking; RADICAL-SCAVENGING ACTIVITY; SPECTRAL CHARACTERIZATION; ANTICANCER; ANTITUMOR; ANTIOXIDANT; COPPER(II); ZINC(II); DRUGS; SITE;

D O I：

10.1080/00958972.2018.1476687

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new Schiff base ligand, H2L, and its Zn(II) complex were prepared and characterized by different analytical and spectroscopic techniques. The elemental analysis results suggest the stoichiometry of the complex to be 1:1. The molar conductance study shows the non-electrolytic nature of the complex. Infrared spectra reveal that the metal ion is coordinated in tetradentate fashion which was further confirmed by NMR study. The synthesized complex was found to interact with CT-DNA quite efficiently. The DNA binding study of the complex was explored by UV-vis and viscosity measurement. Fluorescence titration studies and the experimental results suggest that the complex might bind to DNA via an intercalative mode. The in silico target prediction and molecular docking experiments confirm that, apart from high interaction potentiality with nucleotides, the complex has possible implications in carcinogenesis, too. [GRAPHICS] .

引用

页码：2165 / 2182

页数：18

共 45 条

[1] Spectroscopic study of molecular structures of novel Schiff base derived from o-phthaldehyde and 2-aminophenol and its coordination compounds together with their biological activity [J].