Molecular mechanisms in the regulation of adult neurogenesis during stress

被引：143

作者：

Egeland, Martin ^{[1
]}

Zunszain, Patricia A. ^{[1
]}

Pariante, Carmine M. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, London SE5 9NU, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 04期

基金：

英国医学研究理事会;

关键词：

NEURAL STEM-CELLS; ENDOTHELIAL GROWTH-FACTOR; GLUCOCORTICOID-RECEPTOR PHOSPHORYLATION; ANTAGONIST MIFEPRISTONE NORMALIZES; MOUSE DENTATE GYRUS; CHRONIC MILD STRESS; FACTOR-KAPPA-B; HIPPOCAMPAL NEUROGENESIS; NEUROTROPHIC FACTOR; IN-VIVO;

D O I：

10.1038/nrn3855

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Coping with stress is fundamental for mental health, but understanding of the molecular neurobiology of stress is still in its infancy. Adult neurogenesis is well known to be regulated by stress, and conversely adult neurogenesis regulates stress responses. Recent studies in neurogenic cells indicate that molecular pathways activated by glucocorticoids, the main stress hormones, are modulated by crosstalk with other stress-relevant mechanisms, including inflammatory mediators, neurotrophic factors and morphogen signalling pathways. This Review discusses the pathways that are involved in this crosstalk and thus regulate this complex relationship between adult neurogenesis and stress.

引用

页码：189 / 200

页数：12

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