How bacterial pathogens colonize their hosts and invade deeper tissues

被引:528
作者
Ribet, David [1 ,2 ,3 ]
Cossart, Pascale [1 ,2 ,3 ]
机构
[1] Inst Pasteur, Dept Biol Cellulaire & Infect, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] INSERM, U604, F-75015 Paris, France
[3] INRA, USC2020, F-75015 Paris, France
关键词
Bacterial invasion; Bacterial adhesion; Microbiota; Host barrier; Host-pathogen interactions; Listeria; LISTERIA-MONOCYTOGENES; IV PILI; MAINTAIN HOMEOSTASIS; MUC2; MUCIN; M-CELLS; ADHESION; INVASION; RECEPTOR; INFLAMMATION; TYPHIMURIUM;
D O I
10.1016/j.micinf.2015.01.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:173 / 183
页数:11
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