Copper-Catalyzed Alkynylation of C(sp3)-H Bonds in N-Fluoro-sulfonamides

被引：38

作者：

Yin, Zhiping ^{[1
]}

Zhang, Youcan ^{[2
]}

Zhang, Shuo ^{[3
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Zhejiang, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

[3] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Youdian Rd 54, Hangzhou 310006, Zhejiang, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 23期

关键词：

Copper catalyst; Alkynylation; N-Fluoro-sulfonamides; C(sp(3))-H functionalization; 1; 5-Hydrogen atom transfer; RADICALS; ACTIVATION; OXYGEN;

D O I：

10.1002/adsc.201900992

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we developed a copper-catalyzed approach for the remote C(sp(3))-H alkynylation of N-fluoro-sulfonamides. With Cu(OTf)(2) as the catalyst, the carbon radical which generated from nitrogen radical-mediated 1,5-hydrogen atom transfer, go through an addition/fragmentation reaction with various acetylene sulfones. A variety of internal alkynes were synthesized in high yield and regioselectivity. Notably, celecoxib-derived substrate can also gave the corresponding functionalized product in good yield under the standard conditions.

引用

页码：5478 / 5482

页数：5

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