From biodegradable polymers to bioresorbable vascular scaffolds: available evidence in the era of new-generation drug-eluting stents

被引：0

作者：

Magliulo, Fabio ^{[1
]}

Piccolo, Raffaele ^{[2
]}

Franzone, Anna ^{[2
]}

Esposito, Giovanni ^{[1
]}

Danzi, Gian B. ^{[3
]}

机构：

[1] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy

[2] Bern Univ Hosp, Dept Cardiol, Bern, Switzerland

[3] Osped Santa Corona, Div Cardiol, I-17027 Pietra Ligure, Savona, Italy

来源：

MINERVA CARDIOANGIOLOGICA | 2018年 / 66卷 / 03期

关键词：

Percutaneous coronary intervention; Stents; Drug-eluting stents; Polymers; CORONARY-ARTERY-DISEASE; OPTICAL COHERENCE TOMOGRAPHY; ELEVATION MYOCARDIAL-INFARCTION; 3-YEAR CLINICAL-OUTCOMES; DURABLE-POLYMER; FOLLOW-UP; METALLIC STENTS; RANDOMIZED EVALUATION; DIABETES-MELLITUS; 2-YEAR OUTCOMES;

D O I：

10.23736/S0026-4725.17.04574-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts,biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicates a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES. Recently, polymer-free DES provided promising results particularly as alternative to bare-metal stents. Ultimately, although remaining conceptually solid, bioresorbable vascular scaffolds represent an immature technology owing to increased risk of thrombosis. In this review, we summarized current evidence about contemporary coronary devices.

引用

页码：246 / 261

页数：16

共 93 条

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