A Time to Kill: Targeting Apoptosis in Cancer

被引：224

作者：

Koff, Jean L. ^{[1
]}

Ramachandiran, Sampath ^{[1
]}

Bernal-Mizrachi, Leon ^{[1
]}

机构：

[1] Emory Univ, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 02期

关键词：

NF-KAPPA-B; BH3 MIMETIC ABT-199; CYTOCHROME-C; CELL-DEATH; BCL-2; GENE; FAMILY; SMAC; MUTATIONS; PROTEASE;

D O I：

10.3390/ijms16022942

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.

引用

页码：2942 / 2955

页数：14

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