Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis

被引：364

作者：

Kondo, Naoki ^{[1
]}

Kuroda, Takeshi ^{[2
]}

Kobayashi, Daisuke ^{[3
]}

机构：

[1] Niigata Univ, Div Orthoped Surg, Dept Regenerat & Transplant Med, Grad Sch Med & Dent Sci, 1-757 Asahimachi Dori, Niigata 9518510, Japan

[2] Niigata Univ, Hlth Adm Ctr, Nishi Ku, 2-8050 Ikarashi, Niigata 9502181, Japan

[3] Niigata Univ, Div Clin Nephrol & Rheumatol, Grad Sch Med & Dent Sci, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518510, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期

关键词：

rheumatoid arthritis; TNF-alpha; IL-6; IL-7; IL-17; IL-21; IL-23; GM-CSF; IL-1; beta; IL-18; IL-33; IL-2; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; COLONY-STIMULATING FACTOR; BONE-MINERAL DENSITY; ANTI-INTERLEUKIN-17; MONOCLONAL-ANTIBODY; RANKL-MEDIATED OSTEOCLASTOGENESIS; CHRONIC INFLAMMATORY ARTHRITIS; REGULATORY T-CELLS; TARGETING GM-CSF;

D O I：

10.3390/ijms222010922

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation causing progressive joint damage that can lead to lifelong disability. The pathogenesis of RA involves a complex network of various cytokines and cells that trigger synovial cell proliferation and cause damage to both cartilage and bone. Involvement of the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 is central to the pathogenesis of RA, but recent research has revealed that other cytokines such as IL-7, IL-17, IL-21, IL-23, granulocyte macrophage colony-stimulating factor (GM-CSF), IL-1 beta, IL-18, IL-33, and IL-2 also play a role. Clarification of RA pathology has led to the development of therapeutic agents such as biological disease-modifying anti-rheumatic drugs (DMARDs) and Janus kinase (JAK) inhibitors, and further details of the immunological background to RA are emerging. This review covers existing knowledge regarding the roles of cytokines, related immune cells and the immune system in RA, manipulation of which may offer the potential for even safer and more effective treatments in the future.</p>

引用

页数：27

共 202 条

[21] Anti-tumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis [J].