Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles

被引：37
|
作者：
Zhang, Xu [1 ,2 ]
Zhou, Yu [2 ]
Wang, Hengshuai [2 ]
Guo, Diliang [1 ,2 ]
Ye, Deju [2 ]
Xu, Yungen [1 ]
Jiang, Hualiang [2 ]
Liu, Hong [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
GREEN CHEMISTRY | 2011年 / 13卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ORGANIC-REACTIONS; ANTITUMOR AGENTS; TANDEM SYNTHESIS; BOND ACTIVATION; CYCLIZATION; WATER; HETEROCYCLES; DERIVATIVES; ABILITY; GOLD;
D O I：
10.1039/c0gc00668h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, convenient and green synthetic approach to diverse fused tricyclic benzimidazoles has been developed by Ag(I) complex catalyzed intramolecular hydroamination under the classic method or by microwave irradiation in water. This strategy presents an operationally simple and environmentally friendly transformation, in which various substituted benzimidazoles facilitated efficient cyclization.
引用
收藏
页码：397 / 405
页数：9
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